CFHR1 explained

Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.^{[1] [2] [3]}

Further reading

• Zipfel PF, Skerka C . Complement factor H and related proteins: an expanding family of complement-regulatory proteins? . Immunol. Today . 15 . 3 . 121–6 . 1994 . 8172644 . 10.1016/0167-5699(94)90155-4 .
• Zipfel PF, Jokiranta TS, Hellwage J . The factor H protein family. . Immunopharmacology . 42 . 1–3 . 53–60 . 1999 . 10408366 . 10.1016/S0162-3109(99)00015-6 . etal.
• Timmann C, Leippe M, Horstmann RD . Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions. . J. Immunol. . 146 . 4 . 1265–70 . 1991 . 10.4049/jimmunol.146.4.1265 . 1825108 . 37805964 . free .
• Park CT, Wright SD . Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins. . J. Biol. Chem. . 271 . 30 . 18054–60 . 1996 . 8663389 . 10.1074/jbc.271.30.18054 . free .
• Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D . A radiation hybrid map of complement factor H and factor H-related genes. . Immunogenetics . 49 . 6 . 549–52 . 1999 . 10380701 . 10.1007/s002510050534 . 31776506 .
• Male DA, Ormsby RJ, Ranganathan S . Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes. . Mol. Immunol. . 37 . 1–2 . 41–52 . 2000 . 10781834 . 10.1016/S0161-5890(00)00024-9 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Pérez-Caballero D, García-Laorden I, Cortés G . Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules. . J. Immunol. . 173 . 11 . 6899–904 . 2005 . 15557185 . 10.4049/jimmunol.173.11.6899. etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• McDowell JV, Lankford J, Stamm L . Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans. . Infect. Immun. . 73 . 11 . 7126–32 . 2005 . 16239506 . 10.1128/IAI.73.11.7126-7132.2005 . 1273895 . etal.
• Liu T, Qian WJ, Gritsenko MA . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Zipfel PF, Edey M, Heinen S . Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. . PLOS Genet. . 3 . 3 . e41 . 2007 . 17367211 . 10.1371/journal.pgen.0030041 . 1828695 . etal . free .
• Haupt K, Kraiczy P, Wallich R . Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins. . J. Infect. Dis. . 196 . 1 . 124–33 . 2007 . 17538892 . 10.1086/518509 . etal. free .

External links

• • GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
• OMIM entries on Atypical Hemolytic-Uremic Syndrome

Notes and References

1. Skerka C, Horstmann RD, Zipfel PF . Molecular cloning of a human serum protein structurally related to complement factor H . J Biol Chem . 266 . 18 . 12015–20 . Jul 1991 . 10.1016/S0021-9258(18)99058-7 . 1711047 . free .
2. Estaller C, Koistinen V, Schwaeble W, Dierich MP, Weiss EH . Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule . J Immunol . 146 . 9 . 3190–6 . May 1991 . 10.4049/jimmunol.146.9.3190 . 1826708 . free .
3. Web site: Entrez Gene: CFHR1 complement factor H-related 1.