CEP68 explained

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene.^{[1] [2] [3] [4]} CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.^[5]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Research . 9 . 3 . 99–106 . Jun 2002 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants . Molecular Vision . 8 . 205–20 . Jun 2002 . 12107410 .
• Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK . Rate of evolution in brain-expressed genes in humans and other primates . PLOS Biology . 5 . 2 . e13 . Feb 2007 . 17194215 . 1717015 . 10.1371/journal.pbio.0050013 . free .
• Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP . Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells . Proteomics . 7 . 14 . 2384–97 . Jul 2007 . 17570516 . 10.1002/pmic.200600968 . 23944956 .

Notes and References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 1 . 31–9 . Feb 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
2. Toward a complete human genome sequence . Genome Research . 8 . 11 . 1097–108 . Nov 1998 . 9847074 . 10.1101/gr.8.11.1097 . free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
3. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M . Proteomic characterization of the human centrosome by protein correlation profiling . Nature . 426 . 6966 . 570–4 . Dec 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 .
4. Web site: Entrez Gene: CEP68 centrosomal protein 68kDa.
5. Graser S, Stierhof YD, Nigg EA . Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion . Journal of Cell Science . 120 . Pt 24 . 4321–31 . Dec 2007 . 18042621 . 10.1242/jcs.020248 . 7307094 .