CEP55 explained

Centrosomal protein of 55 kDa (Cep55), is a protein that in humans is encoded by the CEP55 gene.^{[1] [2]}

Cep55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.^[3] and cilia formation in neural stem cells.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal . free.
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K . The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody . Genomics . 87 . 2 . 243–53 . 2006 . 16406728 . 10.1016/j.ygeno.2005.11.006 . free.
• Zhao WM, Seki A, Fang G . Cep55, a Microtubule-bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis . Mol. Biol. Cell . 17 . 9 . 3881–96 . 2006 . 16790497 . 10.1091/mbc.E06-01-0015 . 1593165.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free.
• Chen CH, Lu PJ, Chen YC . FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway . Oncogene . 26 . 29 . 4272–83 . 2007 . 17237822 . 10.1038/sj.onc.1210207 . etal. free.
• Carlton JG, Martin-Serrano J . Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery . Science . 316 . 5833 . 1908–12 . 2007 . 17556548 . 10.1126/science.1143422 . 2007Sci...316.1908C . 29191843 . free .
• Morita E, Sandrin V, Chung HY . Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis . EMBO J. . 26 . 19 . 4215–27 . 2007 . 17853893 . 10.1038/sj.emboj.7601850 . 2230844 . etal.

Notes and References

1. Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK . Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis . Dev Cell . 9 . 4 . 477–88 . Oct 2005 . 16198290 . 10.1016/j.devcel.2005.09.003 . free.
2. Web site: Entrez Gene: CEP55 centrosomal protein 55kDa.
3. van der Horst A, Simmons J, Khanna KK . Cep55 stabilization is required for normal execution of cytokinesis . Cell Cycle . 8 . 22 . 3742–3749 . November 2009 . 19855176 . 10.4161/cc.8.22.10047 . free.
4. Behnam Rashidieh . Belal Shohayeb . Amanda Louise Bain . Patrick R. J. Fortuna . Debottam Sinha . Andrew Burgess . Richard Mills . Rachael C. Adams . J. Alejandro Lopez . Peter Blumbergs . John Finnie . Murugan Kalimutho . Michael Piper . James Edward Hudson . Dominic C. H. Ng . Kum Kum Khanna . Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis . PLOS Genetics . October 2021 . 17 . 10 . e1009334 . 34710087 . 10.1371/journal.pgen.1009334 . 8577787 . free.