CEP164 explained

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene.^[1] ^[2] Its function appears two be twofold: CEP164 is required for primary cilium formation.^[3] Furthermore, it is an important component in the response to DNA damage by UV light.^[4] ^[5]

Further reading

Graser S, Stierhof YD, Lavoie SB . Cep164, a novel centriole appendage protein required for primary cilium formation . J. Cell Biol. . 179 . 2 . 321–30 . 2007 . 17954613 . 2064767 . 10.1083/jcb.200707181 . etal.
Golsteyn RM, Mundt KE, Fry AM, Nigg EA . Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function . J. Cell Biol. . 129 . 6 . 1617–28 . 1995 . 7790358 . 2291169 . 10.1083/jcb.129.6.1617 .
Casenghi M, Meraldi P, Weinhart U . Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation . Dev. Cell . 5 . 1 . 113–25 . 2003 . 12852856 . 10.1016/S1534-5807(03)00193-X . etal. free .
Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
Mayor T, Stierhof YD, Tanaka K . The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion . J. Cell Biol. . 151 . 4 . 837–46 . 2000 . 11076968 . 2169446 . 10.1083/jcb.151.4.837 . etal.
Sivasubramaniam S, Sun X, Pan YR . Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 . Genes Dev. . 22 . 5 . 587–600 . 2008 . 18283122 . 2259029 . 10.1101/gad.1627708 . etal.
Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
Petretti C, Savoian M, Montembault E . The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation . EMBO Rep. . 7 . 4 . 418–24 . 2006 . 16462731 . 1456919 . 10.1038/sj.embor.7400639 . etal.
Zick A, Onn I, Bezalel R . Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements . Nucleic Acids Res. . 33 . 13 . 4235–42 . 2005 . 16052032 . 1181863 . 10.1093/nar/gki742 . etal.
Pan YR, Lee EY . UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity . Cell Cycle . 8 . 4 . 655–64 . 2009 . 19197159 . 10.4161/cc.8.4.7844 . free .
Takahashi M, Yamagiwa A, Nishimura T . Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex . Mol. Biol. Cell . 13 . 9 . 3235–45 . 2002 . 12221128 . 124155 . 10.1091/mbc.E02-02-0112 . etal.

Notes and References

Web site: Entrez Gene: centrosomal protein 164kDa.
Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M . Proteomic characterization of the human centrosome by protein correlation profiling . Nature . 426 . 6966 . 570–4 . December 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 .
10.1083/jcb.200707181 . 2064767 . Cep164, a novel centriole appendage protein required for primary cilium formation . 17954613 . 2007 . Graser . S. . Stierhof . Y. -D. . Lavoie . S. B. . Gassner . O. S. . Lamla . S. . Le Clech . M. . Nigg . E. A. . The Journal of Cell Biology . 179 . 2 . 321–30.
10.1101/gad.1627708 . 2259029 . Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 . 18283122 . 2008 . Sivasubramaniam . S. . Sun . X. . Pan . Y. -R. . Wang . S. . Lee . E. Y. -H. P. . Eva Y.-H. P. Lee. Genes & Development . 22 . 5 . 587–600.
19197159 . 2009 . Pan . YR . Lee . EY . UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity . 8 . 4 . 655–64 . Cell Cycle. 10.4161/cc.8.4.7844. free .