CEP152 explained

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene.^[1] It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.^[2]

Further reading

• Nakayama M, Kikuno R, Ohara O . Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2002 . 12421765 . 187542 . 10.1101/gr.406902 .
• Nagase T, Ishikawa K, Suyama M . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 6 . 355–64 . 1998 . 10048485 . 10.1093/dnares/5.6.355. etal. free .
• Andersen JS, Wilkinson CJ, Mayor T . Proteomic characterization of the human centrosome by protein correlation profiling . Nature . 426 . 6966 . 570–4 . 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 . etal.
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA . Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function . J. Cell Biol. . 129 . 6 . 1617–28 . 1995 . 7790358 . 2291169 . 10.1083/jcb.129.6.1617 .
• Casenghi M, Meraldi P, Weinhart U . Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation . Dev. Cell . 5 . 1 . 113–25 . 2003 . 12852856 . 10.1016/S1534-5807(03)00193-X . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• Mayor T, Stierhof YD, Tanaka K . The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion . J. Cell Biol. . 151 . 4 . 837–46 . 2000 . 11076968 . 2169446 . 10.1083/jcb.151.4.837 . etal.
• Petretti C, Savoian M, Montembault E . The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation . EMBO Rep. . 7 . 4 . 418–24 . 2006 . 16462731 . 1456919 . 10.1038/sj.embor.7400639 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Takahashi M, Yamagiwa A, Nishimura T . Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex . Mol. Biol. Cell . 13 . 9 . 3235–45 . 2002 . 12221128 . 124155 . 10.1091/mbc.E02-02-0112 . etal.

Notes and References

1. Web site: Entrez Gene: centrosomal protein 152kDa.
2. Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T . Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication . Genetics . 180 . 4 . 2081–94 . December 2008 . 18854586 . 2600943 . 10.1534/genetics.108.095141 .