CENTG1 explained
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.[1]
Interactions
CENTG1 has been shown to interact with:
Further reading
- Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N . Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. . DNA Res. . 3 . 1 . 17–24 . 1996 . 8724849 . 10.1093/dnares/3.1.17 . free .
- Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS . Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. . Genomics . 42 . 2 . 295–301 . 1997 . 9192850 . 10.1006/geno.1997.4727 .
- Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH . Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. . Cell . 103 . 6 . 919–30 . 2001 . 11136977 . 10.1016/S0092-8674(00)00195-1 . 16610638 . free .
- Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH . Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. . Nature . 415 . 6871 . 541–4 . 2002 . 11823862 . 10.1038/415541a . 4371421 .
- Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA . AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton. . J. Biol. Chem. . 277 . 50 . 48965–75 . 2003 . 12388557 . 10.1074/jbc.M202969200 . free .
- Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M . GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. . Mol. Cell. Biol. . 23 . 7 . 2476–88 . 2003 . 12640130 . 150724 . 10.1128/MCB.23.7.2476-2488.2003 .
- Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K . PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. . Nat. Neurosci. . 6 . 11 . 1153–61 . 2003 . 14528310 . 10.1038/nn1134 . 807407 .
- Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K . PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. . J. Biol. Chem. . 279 . 16 . 16441–51 . 2004 . 14761976 . 10.1074/jbc.M312175200 . free .
- Ahn JY, Hu Y, Kroll TG, Allard P, Ye K . PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 18 . 6993–8 . 2004 . 15118108 . 406454 . 10.1073/pnas.0400921101 . 2004PNAS..101.6993A . free .
- Nie Z, Fei J, Premont RT, Randazzo PA . The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. . J. Cell Sci. . 118 . Pt 15 . 3555–66 . 2005 . 16079295 . 10.1242/jcs.02486 . free .
- Knobbe CB, Trampe-Kieslich A, Reifenberger G . Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. . Neuropathol. Appl. Neurobiol. . 31 . 5 . 486–90 . 2005 . 16150119 . 10.1111/j.1365-2990.2005.00660.x . 21766234 .
- Hu Y, Liu Z, Ye K . Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. . Proc. Natl. Acad. Sci. U.S.A. . 102 . 46 . 16853–8 . 2006 . 16263930 . 1283830 . 10.1073/pnas.0507365102 . free .
- Tang X, Feng Y, Ye K . Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. . Cell Death Differ. . 14 . 2 . 368–77 . 2007 . 16841086 . 10.1038/sj.cdd.4402011 . free .
- Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA . The centaurin gamma-1 GTPase-like domain functions as an NTPase. . Biochem. J. . 401 . 3 . 679–88 . 2007 . 17037982 . 1770848 . 10.1042/BJ20060555 .
- Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G . M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. . J. Virol. . 81 . 5 . 2340–8 . 2007 . 17151107 . 1865929 . 10.1128/JVI.01310-06 .
- Liu X, Hu Y, Hao C, Rempel SA, Ye K . PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion. . Oncogene . 26 . 34 . 4918–27 . 2007 . 17297440 . 10.1038/sj.onc.1210290 . 1156814 .
- Dunphy JL, Ye K, Casanova JE . Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2. . Traffic . 8 . 6 . 661–72 . 2007 . 17461797 . 10.1111/j.1600-0854.2007.00561.x . 28218061 . free .
Notes and References
- Web site: Entrez Gene: CENTG1 centaurin, gamma 1.
- Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K . PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis . Nat. Neurosci. . 6 . 11 . 1153–61 . November 2003 . 14528310 . 10.1038/nn1134 . 807407 .
- Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH . Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N . Cell . 103 . 6 . 919–30 . December 2000 . 11136977 . 10.1016/S0092-8674(00)00195-1. 16610638 . free .