CENTD3 explained

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.^{[1] [2] [3]}

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.

Further reading

• Raaijmakers JH . The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner . Cell. Signal. . 19 . 6 . 1249–57 . 2007 . 17314030 . 10.1016/j.cellsig.2006.12.015 . Deneubourg L . Rehmann H . De Koning . John . Zhang . Zhongchun . Krugmann . Sonja . Erneux . Christophe . Bos . Johannes L. . 1874/35664 . 356352 . free .
• Lu Q . EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin . Proc. Natl. Acad. Sci. U.S.A. . 101 . 49 . 17246–51 . 2005 . 15569923 . 10.1073/pnas.0407794101 . 534609 . Wei W . Kowalski PE . Chang . AC . Cohen . SN . free .
• I ST . ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner . J. Cell Sci. . 117 . Pt 25 . 6071–84 . 2005 . 15546919 . 10.1242/jcs.01526 . Nie Z . Stewart A . Najdovska . M . Hall . NE . He . H . Randazzo . PA . Lock . P . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Reinhard C, Schweikert M, Wieland FT, Nickel W . Functional reconstitution of COPI coat assembly and disassembly using chemically defined components . Proc. Natl. Acad. Sci. U.S.A. . 100 . 14 . 8253–7 . 2003 . 12832619 . 10.1073/pnas.1432391100 . 166215 . 2003PNAS..100.8253R . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT . Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices . Mol Cell . 9 . 1 . 95–108 . Jan 2002 . 11804589 . 10.1016/S1097-2765(02)00434-3 . free .
2. Santy LC, Casanova JE . GTPase signaling: bridging the GAP between ARF and Rho . Curr Biol . 12 . 10 . R360–2 . May 2002 . 12015138 . 10.1016/S0960-9822(02)00860-6 . 15875666 . free . 2002CBio...12.R360S .
3. Web site: Entrez Gene: CENTD3 centaurin, delta 3.