CENPO explained

Centromere protein O is a protein that in humans is encoded by the CENPO gene.^{[1] [2] [3]} CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. ^[4]

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Obuse C, Yang H, Nozaki N . Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. . Genes Cells . 9 . 2 . 105–20 . 2004 . 15009096 . 10.1111/j.1365-2443.2004.00705.x . 21813024 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Izuta H, Ikeno M, Suzuki N . Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. . Genes Cells . 11 . 6 . 673–84 . 2006 . 16716197 . 10.1111/j.1365-2443.2006.00969.x . 45931410 . etal. free .

Notes and References

1. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T . The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres . Nat Cell Biol . 8 . 5 . 446–57 . May 2006 . 16622420 . 10.1038/ncb1396 . 26974412 .
2. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW . The human CENP-A centromeric nucleosome-associated complex . Nat Cell Biol . 8 . 5 . 458–69 . May 2006 . 16622419 . 10.1038/ncb1397 . 205286556 .
3. Web site: Entrez Gene: CENPO centromere protein O.
4. Hewitt. Chelsee A.. Ling. King-Hwa. Merson. Tobias D.. Simpson. Ken M.. Ritchie. Matthew E.. King. Sarah L.. Pritchard. Melanie A.. Smyth. Gordon K.. Thomas. Tim. 2010-07-16. Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome. PLOS ONE. 5. 7. e11561. 10.1371/journal.pone.0011561. 1932-6203. 2905390. 20661276. 2010PLoSO...511561H . free.