CENPM explained

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.^{[1] [2] [3]}

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.^{[4] [5]} Centromere protein M is involved in centromere assembly and immune response.^[6]

Further reading

• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K . Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase . Genes to Cells . 9 . 2 . 105–20 . February 2004 . 15009096 . 10.1111/j.1365-2443.2004.00705.x . 21813024 . free .
• Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K . Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells . Genes to Cells . 11 . 6 . 673–84 . June 2006 . 16716197 . 10.1111/j.1365-2443.2006.00969.x . free .

Notes and References

1. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T . The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres . Nature Cell Biology . 8 . 5 . 446–57 . May 2006 . 16622420 . 10.1038/ncb1396 . 26974412 .
2. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW . The human CENP-A centromeric nucleosome-associated complex . Nature Cell Biology . 8 . 5 . 458–69 . May 2006 . 16622419 . 10.1038/ncb1397 . 205286556 .
3. Web site: Entrez Gene: CENPM centromere protein M.
4. Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH . The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL . Blood . 107 . 9 . 3779–86 . 2006 . 16391015 . 1895781 . 10.1182/blood-2005-08-3501 .
5. Bierie B, Edwin M, Melenhorst JJ, Hennighausen L . The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells . Gene Expression Patterns . 4 . 4 . 389–95 . July 2004 . 15183305 . 10.1016/j.modgep.2004.01.008 .
6. Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K . Molecular characterization and association analysis of porcine PANE1 gene . Molecular Biology Reports . 37 . 5 . 2571–7 . 2010 . 19711193 . 10.1007/s11033-009-9775-0 . 20345149 .