CENPI explained

Centromere protein I is a protein that in humans is encoded by the CENPI gene.^{[1] [2]}

Function

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.^[2] CENPI is a target gene of the transcription factor E2F.^[3] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.^[3]

Further reading

• Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K . Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells . Genes to Cells . 11 . 6 . 673–84 . June 2006 . 16716197 . 10.1111/j.1365-2443.2006.00969.x . free .
• Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW . The human CENP-A centromeric nucleosome-associated complex . Nature Cell Biology . 8 . 5 . 458–69 . May 2006 . 16622419 . 10.1038/ncb1397 . 205286556 .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–6 . April 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .
• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K . Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase . Genes to Cells . 9 . 2 . 105–20 . February 2004 . 15009096 . 10.1111/j.1365-2443.2004.00705.x . 21813024 . free .
• Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ . Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis . Nature Cell Biology . 5 . 4 . 341–5 . April 2003 . 12640463 . 10.1038/ncb953 . 33165992 .
• Roberts RG, Kendall E, Vetrie D, Bobrow M . Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene . Genomics . 37 . 1 . 122–4 . October 1996 . 8921378 . 10.1006/geno.1996.0528 .
• Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA . Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein . Molecular and Cellular Endocrinology . 108 . 1–2 . 115–24 . February 1995 . 7758824 . 10.1016/0303-7207(94)03468-9 . 1765/64471 . 11122437 . free .
• Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC . Sequence identification of 2,375 human brain genes . Nature . 355 . 6361 . 632–4 . February 1992 . 1538749 . 10.1038/355632a0 . 1992Natur.355..632A . 4234345 .

Notes and References

1. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T . The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres . Nature Cell Biology . 8 . 5 . 446–57 . May 2006 . 16622420 . 10.1038/ncb1396 . 26974412 .
2. Web site: Entrez Gene: CENPI centromere protein I.
3. Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH . CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer . Oncotarget . 8 . 37 . 62167–62182 . September 2017 . 28977935 . 10.18632/oncotarget.19131 . 5617495 .