CEMIP explained

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene.^[1] CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases.^[2] Such function has also been validated in mice.^[3]

CEMIP is associated with nonsyndromic deafness,^[4] as well as a variety of cancers.^[5]

Further reading

• Nagase T, Ishikawa K, Kikuno R, etal . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 5 . 337–45 . 2000 . 10574462 . 10.1093/dnares/6.5.337 . free .
• Wines ME, Lee L, Katari MS, etal . Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. . Genomics . 72 . 1 . 88–98 . 2001 . 11247670 . 10.1006/geno.2000.6466 .
• Nakayama M, Kikuno R, Ohara O . Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Abe S, Katagiri T, Saito-Hisaminato A, etal . Identification of CRYM as a Candidate Responsible for Nonsyndromic Deafness, through cDNA Microarray Analysis of Human Cochlear and Vestibular Tissues . Am. J. Hum. Genet. . 72 . 1 . 73–82 . 2003 . 12471561 . 10.1086/345398 . 420014 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Guo J, Cheng H, Zhao S, Yu L . GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases . FEBS Lett. . 580 . 2 . 581–4 . 2006 . 16406369 . 10.1016/j.febslet.2005.12.076 . 1013478 .

Notes and References

1. Web site: Entrez Gene: KIAA1199 KIAA1199.
2. Yoshida. H.. Nagaoka. A.. Kusaka-Kikushima. A.. Tobiishi. M.. Kawabata. K.. Sayo. T.. Sakai. S.. Sugiyama. Y.. Enomoto. H.. Okada. Y.. Inoue. S.. KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization. Proceedings of the National Academy of Sciences. 18 March 2013. 110. 14. 5612–5617. 10.1073/pnas.1215432110. 23509262. 3619336. 2013PNAS..110.5612Y . free.
3. Yoshida. Hiroyuki. Nagaoka. Aya. Nakamura. Sachiko. Sugiyama. Yoshinori. Okada. Yasunori. Inoue. Shintaro. Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization. FEBS Open Bio. 17 August 2013. 3. 1. 352–356. 10.1016/j.fob.2013.08.003. 3821019. 24251095.
4. Abe S, Usami S, Nakamura Y . Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss . J Hum Genet . 48 . 11 . 564–70 . Nov 2003 . 14577002 . 10.1007/s10038-003-0079-2 . free .
5. Zhang. Yongsheng. Jia. Shuqin. Jiang. Wen. KIAA1199 and its biological role in human cancer and cancer cells (Review). Oncology Reports. 20 February 2014. 31. 4. 1503–1508. 10.3892/or.2014.3038. 24573670. free.