CELSR3 explained

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.^{[1] [2]}

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.

See also

• Flamingo (protein)

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Wu Q, Maniatis T . A striking organization of a large family of human neural cadherin-like cell adhesion genes . Cell . 97 . 6 . 779–90 . 1999 . 10380929 . 10.1016/S0092-8674(00)80789-8 . 6014717 . free .
• Wu Q, Maniatis T . Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3124–9 . 2000 . 10716726 . 10.1073/pnas.060027397 . 16203 . free .
• Formstone CJ, Barclay J, Rees M, Little PF . Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9 . Mamm. Genome . 11 . 5 . 392–4 . 2000 . 10790539 . 10.1007/s003350010073 . 21333332 .
• Nakayama M, Kikuno R, Ohara O . Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Bjarnadóttir TK, Fredriksson R, Höglund PJ . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors . Genomics . 84 . 1 . 23–33 . 2005 . 15203201 . 10.1016/j.ygeno.2003.12.004 . etal.

Notes and References

1. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O . Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening . Genomics . 51 . 1 . 27–34 . Sep 1998 . 9693030 . 10.1006/geno.1998.5341 .
2. Web site: Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila).