CELSR2 explained

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.^[1]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.^[2]

See also

• Flamingo (protein)

Further reading

• Nagase T, Seki N, Ishikawa K . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. . DNA Res. . 3 . 5 . 321–9, 341–54 . 1997 . 9039502 . 10.1093/dnares/3.5.321 . etal. free .
• Wu Q, Maniatis T . A striking organization of a large family of human neural cadherin-like cell adhesion genes. . Cell . 97 . 6 . 779–90 . 1999 . 10380929 . 10.1016/S0092-8674(00)80789-8 . 6014717 . free .
• Wu Q, Maniatis T . Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3124–9 . 2000 . 10716726 . 10.1073/pnas.060027397 . 16203 . free .
• Vincent JB, Skaug J, Scherer SW . The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1 . DNA Res. . 7 . 3 . 233–5 . 2001 . 10907856 . 10.1093/dnares/7.3.233 . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O . Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening . Genomics . 51 . 1 . 27–34 . Sep 1998 . 9693030 . 10.1006/geno.1998.5341 .
2. Web site: Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila).