CELA2B explained

Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.^{[1] [2] [3]}

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.^[3]

Further reading

• Fletcher TS, Shen WF, Largman C . Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA . Biochemistry . 26 . 23 . 7256–61 . 1987 . 3427074 . 10.1021/bi00397a010 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• Hosgood HD, Zhang L, Shen M . Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity . Occup Environ Med . 66 . 12 . 848–53 . 2009 . 19773279 . 2928224 . 10.1136/oem.2008.044024 . etal.

Notes and References

1. Kawashima I, Tani T, Shimoda K, Takiguchi Y . Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas . DNA . 6 . 2 . 163–72 . April 1987 . 3646943 . 10.1089/dna.1987.6.163.
2. Szepessy E, Sahin-Tóth M . Inactivity of Recombinant ELA2B Provides a New Example of Evolutionary Elastase Silencing in Humans . Pancreatology . 6 . 1–2 . 117–22 . 2006 . 16327289 . 1447606 . 10.1159/000090031 .
3. Web site: Entrez Gene: chymotrypsin-like elastase family.