CELA2A explained

Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.^{[1] [2] [3]}

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.^[3]

Further reading

• Moulard M, Michon T, Kerfelec B, Chapus C . Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. . FEBS Lett. . 261 . 1 . 179–83 . 1990 . 2307232 . 10.1016/0014-5793(90)80665-6 . free .
• Fletcher TS, Shen WF, Largman C . Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. . Biochemistry . 26 . 23 . 7256–61 . 1988 . 3427074 . 10.1021/bi00397a010 .
• Friess H, Ding J, Kleeff J . Identification of disease-specific genes in chronic pancreatitis using DNA array technology. . Ann. Surg. . 234 . 6 . 769–78; discussion 778–9 . 2002 . 11729383 . 10.1097/00000658-200112000-00008 . 1422136. etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Lausen J, Liu S, Fliegauf M . ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. . Oncogene . 25 . 9 . 1349–57 . 2006 . 16247445 . 10.1038/sj.onc.1209181 . etal. free .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .

Notes and References

1. Kawashima I, Tani T, Shimoda K, Takiguchi Y . Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas . DNA . 6 . 2 . 163–72 . Jul 1987 . 3646943 . 10.1089/dna.1987.6.163.
2. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A . Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2 . J Biochem . 102 . 6 . 1555–63 . Jun 1988 . 10.1093/oxfordjournals.jbchem.a122204 . 2834346 . etal.
3. Web site: Entrez Gene: ELA2A elastase 2A.