CEACAM8 explained

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b), is a member of the carcinoembryonic antigen (CEA) gene family. Its main function is cell adhesion, cell migration, and pathogen binding.^[1]

Use

CEACAM8 is expressed exclusively on granulocytes and used as granulocyte marker.

See also

• Cluster of differentiation

Further reading

• Khan WN, Frängsmyr L, Teglund S . Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. . Genomics . 14 . 2 . 384–90 . 1992 . 1427854 . 10.1016/S0888-7543(05)80230-7 . etal.
• Oikawa S, Inuzuka C, Kuroki M . A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. . J. Biol. Chem. . 266 . 13 . 7995–8001 . 1991 . 10.1016/S0021-9258(18)92930-3 . 2022629 . etal. free .
• Berling B, Kolbinger F, Grunert F . Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. . Cancer Res. . 50 . 20 . 6534–9 . 1990 . 2208113 . etal.
• Arakawa F, Kuroki M, Misumi Y . Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. . Biochem. Biophys. Res. Commun. . 166 . 3 . 1063–71 . 1990 . 2306228 . 10.1016/0006-291X(90)90975-S . etal.
• Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W . Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. . Blood . 91 . 2 . 663–72 . 1998 . 9427723 . 10.1182/blood.V91.2.663. free .
• Torsteinsdóttir I, Arvidson NG, Hällgren R, Håkansson L . Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. . Scand. J. Immunol. . 50 . 4 . 433–9 . 1999 . 10520185 . 10.1046/j.1365-3083.1999.00602.x . 5692060 .
• Oikawa S, Sugiyama M, Kuroki M . Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8. . Biochem. Biophys. Res. Commun. . 278 . 3 . 564–8 . 2001 . 11095950 . 10.1006/bbrc.2000.3858 . etal.
• Singer BB, Scheffrahn I, Heymann R . Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. . J. Immunol. . 168 . 10 . 5139–46 . 2002 . 11994468 . 10.4049/jimmunol.168.10.5139. etal. free .
• Zhao L, Xu S, Peterson C . Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. . J. Immunol. Methods . 270 . 1 . 27–35 . 2002 . 12379336 . 10.1016/s0022-1759(02)00215-6. etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Grimwood J, Gordon LA, Olsen A . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ramachandran P, Boontheung P, Xie Y . Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. . J. Proteome Res. . 5 . 6 . 1493–503 . 2006 . 16740002 . 10.1021/pr050492k . etal.

External links

• • • PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)

Notes and References

1. Web site: Entrez Gene: CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8.