CEACAM6 explained

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c (Cluster of Differentiation 66c), is a member of the carcinoembryonic antigen (CEA) gene family..^[1]

See also

• Cluster of differentiation

Further reading

• Oikawa S, Inuzuka C, Kuroki M . A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. . J. Biol. Chem. . 266 . 13 . 7995–8001 . 1991 . 10.1016/S0021-9258(18)92930-3 . 2022629 . etal. free .
• Haus O, Noworolska A, Laskowski M . Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia. . Exp. Mol. Pathol. . 52 . 2 . 235–42 . 1990 . 2332039 . 10.1016/0014-4800(90)90008-2 . etal.
• Hefta SA, Paxton RJ, Shively JE . Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry. . J. Biol. Chem. . 265 . 15 . 8618–26 . 1990 . 10.1016/S0021-9258(19)38932-X . 2341397 . free .
• Inazawa J, Abe T, Inoue K . Regional assignment of nonspecific cross-reacting antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2. . Cytogenet. Cell Genet. . 52 . 1–2 . 28–31 . 1990 . 2612212 . 10.1159/000132833 . etal.
• Neumaier M, Zimmermann W, Shively L . Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen . J. Biol. Chem. . 263 . 7 . 3202–7 . 1988 . 10.1016/S0021-9258(18)69055-6 . 2830274 . etal. free .
• Kuroki M, Kuroki M, Moore GE . The molecular heterogeneity of nonspecific cross-reacting antigen synthesized by tumor cells and granulocytes . Jpn. J. Cancer Res. . 79 . 1 . 82–90 . 1988 . 3128509 . 10.1111/j.1349-7006.1988.tb00014.x . etal. 5907763 .
• Barnett T, Goebel SJ, Nothdurft MA, Elting JJ . Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains . Genomics . 3 . 1 . 59–66 . 1989 . 3220478 . 10.1016/0888-7543(88)90160-7 .
• Tawaragi Y, Oikawa S, Matsuoka Y . Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence . Biochem. Biophys. Res. Commun. . 150 . 1 . 89–96 . 1988 . 3337731 . 10.1016/0006-291X(88)90490-1 . etal.
• Noworolska A, Harłozińska-Szmyrka A, Richter R . Distribution of surface nonspecific cross-reacting antigen and influence of proteolytic enzymes on this antigen in myeloid cell series . Cancer Detect. Prev. . 9 . 3–4 . 365–71 . 1986 . 3527416 .
• Oikawa S, Kosaki G, Nakazato H . Molecular cloning of a gene for a member of carcinoembryonic antigen (CEA) gene family; signal peptide and N-terminal domain sequences of nonspecific crossreacting antigen (NCA) . Biochem. Biophys. Res. Commun. . 146 . 2 . 464–9 . 1987 . 3619891 . 10.1016/0006-291X(87)90552-3 .
• Watt SM, Fawcett J, Murdoch SJ . CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant . Blood . 84 . 1 . 200–10 . 1994 . 8018919 . 10.1182/blood.V84.1.200.200. etal. free .
• Honda Y, Egawa K, Kuroki M, Ono T . Hair cycle-dependent expression of a nonspecific cross reacting antigen (NCA)-50/90-like molecule on follicular keratinocytes . Arch. Dermatol. Res. . 289 . 8 . 457–65 . 1997 . 9266023 . 10.1007/s004030050221 . 8163767 .
• Schölzel S, Zimmermann W, Schwarzkopf G . Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas . Am. J. Pathol. . 156 . 2 . 595–605 . 2000 . 10666389 . 10.1016/S0002-9440(10)64764-5. 1850034 . etal.
• Oikawa S, Sugiyama M, Kuroki M . Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8 . Biochem. Biophys. Res. Commun. . 278 . 3 . 564–8 . 2001 . 11095950 . 10.1006/bbrc.2000.3858 . etal.
• Ilantzis C, DeMarte L, Screaton RA, Stanners CP . Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation . Neoplasia . 4 . 2 . 151–63 . 2002 . 11896570 . 10.1038/sj.neo.7900201. 1550325 .
• Singer BB, Scheffrahn I, Heymann R . Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes . J. Immunol. . 168 . 10 . 5139–46 . 2002 . 11994468 . 10.4049/jimmunol.168.10.5139. etal. free .
• Skubitz KM, Campbell KD, Skubitz AP . Synthetic peptides from the N-domains of CEACAMs activate neutrophils . J. Pept. Res. . 58 . 6 . 515–26 . 2002 . 12005421 . 10.1034/j.1399-3011.2001.00931.x . 7162001 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Taheri M, Saragovi HU, Stanners CP . The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked . J. Biol. Chem. . 278 . 17 . 14632–9 . 2003 . 12571231 . 10.1074/jbc.M212500200 . free .
• Duxbury MS, Ito H, Zinner MJ . CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells . Oncogene . 23 . 2 . 465–73 . 2004 . 14724575 . 10.1038/sj.onc.1207036 . etal. free .

Notes and References

1. Web site: Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen).