CEACAM3 explained

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a member of the carcinoembryonic antigen (CEA) gene family..^[1]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Use

CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.^[2]

See also

• Cluster of differentiation

Further reading

• Khan WN, Frängsmyr L, Teglund S . Identification of three new genes and estimation of the size of the carcinoembryonic antigen family . Genomics . 14 . 2 . 384–90 . 1992 . 1427854 . 10.1016/S0888-7543(05)80230-7 . etal.
• Kuroki M, Arakawa F, Matsuo Y . Molecular cloning of nonspecific cross-reacting antigens in human granulocytes . J. Biol. Chem. . 266 . 18 . 11810–7 . 1991 . 10.1016/S0021-9258(18)99029-0 . 2050678 . etal. free .
• Thompson JA, Mauch EM, Chen FS . Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons . Biochem. Biophys. Res. Commun. . 158 . 3 . 996–1004 . 1989 . 2537643 . 10.1016/0006-291X(89)92821-0 . etal. 10.1.1.657.2780 .
• Watt SM, Fawcett J, Murdoch SJ . CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant . Blood . 84 . 1 . 200–10 . 1994 . 8018919 . 10.1182/blood.V84.1.200.200. etal. free .
• Nagel G, Grunert F, Kuijpers TW . Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family . Eur. J. Biochem. . 214 . 1 . 27–35 . 1993 . 8508798 . 10.1111/j.1432-1033.1993.tb17892.x . etal. free .
• Skubitz KM, Campbell KD, Skubitz AP . CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils . J. Leukoc. Biol. . 60 . 1 . 106–17 . 1996 . 8699114 . 10.1002/jlb.60.1.106. 46292936 .
• Streichert T, Ebrahimnejad A, Ganzer S . The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes . Biochem. Biophys. Res. Commun. . 289 . 1 . 191–7 . 2001 . 11708798 . 10.1006/bbrc.2001.5955 . etal.
• Skubitz KM, Campbell KD, Skubitz AP . Synthetic peptides from the N-domains of CEACAMs activate neutrophils . J. Pept. Res. . 58 . 6 . 515–26 . 2002 . 12005421 . 10.1034/j.1399-3011.2001.00931.x . 7162001 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Booth JW, Telio D, Liao EH . Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae . J. Biol. Chem. . 278 . 16 . 14037–45 . 2003 . 12571236 . 10.1074/jbc.M211879200 . etal. free .
• McCaw SE, Schneider J, Liao EH . Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor . Mol. Microbiol. . 49 . 3 . 623–37 . 2003 . 12864848 . 10.1046/j.1365-2958.2003.03591.x . 12071872 . etal. free .
• Schmitter T, Agerer F, Peterson L . Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens . J. Exp. Med. . 199 . 1 . 35–46 . 2004 . 14707113 . 10.1084/jem.20030204 . 1887732 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Gimbergues P, Dauplat MM, Cayre A . Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category . Eur J Surg Oncol . 33 . 1 . 16–22 . 2007 . 17071045 . 10.1016/j.ejso.2006.09.013 . etal.
• Gasser M, Gerstlauer C, Grimm M . Comparative analysis of predictive biomarkers for therapeutical strategies in colorectal cancer . Ann. Surg. Oncol. . 14 . 4 . 1272–84 . 2007 . 17211733 . 10.1245/s10434-006-9155-0 . 19408520 . etal.
• Howell NR, Zheng W, Cheng L . Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis? . Int. J. Gynecol. Pathol. . 26 . 2 . 134–40 . 2007 . 17413979 . 10.1097/01.pgp.0000233166.56385.d0 . 534457 . etal.
• Stern-Ginossar N, Nedvetzki S, Markel G . Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells . J. Immunol. . 179 . 7 . 4424–34 . 2007 . 17878338 . 10.4049/jimmunol.179.7.4424. etal. free .

Notes and References

1. Web site: Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3.
2. CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.