CEACAM16 explained

carcinoembryonic antigen-related cell adhesion molecule 16
Hgncid:	31948
Symbol:	CEACAM16
Entrezgene:	388551
Refseq:	XM_371177
Uniprot:	Q2WEN9
Chromosome:	19
Arm:	q
Band:	13.31

Carcinoembryonic antigen-related cell adhesion molecule 16 is encoded in the human by the CEACAM16 gene. It is a member of the carcinoembryonic antigen family, a cluster of genes on chromosome 19. CEACAM16 is a structure of the tectorial membraneinvolved in hearing at low and high frequencies. It is the only carcinoembryonic antigen found in the platypus.^[1] The protein is expressed in mammalian outer hair cells, and mutations in this gene are associated with autosomal dominant nonsyndromic deafness.^{[2] [3]}

Notes and References

1. Kammerer R, Rüttiger L, Riesenberg R, Schäuble C, Krupar R, Kamp A, Sunami K, Eisenried A, Hennenberg M, Grunert F, Bress A, Battaglia S, Schrewe H, Knipper M, Schneider MR, Zimmermann W . 6 . Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies . The Journal of Biological Chemistry . 287 . 26 . 21584–21598 . June 2012 . 22544735 . 10.1074/jbc.M111.320481 . 3381124 . free .
2. Zheng J, Miller KK, Yang T, Hildebrand MS, Shearer AE, DeLuca AP, Scheetz TE, Drummond J, Scherer SE, Legan PK, Goodyear RJ, Richardson GP, Cheatham MA, Smith RJ, Dallos P . 6 . Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4) . Proceedings of the National Academy of Sciences of the United States of America . 108 . 10 . 4218–4223 . March 2011 . 21368133 . 3054008 . 10.1073/pnas.1005842108 . free . 2011PNAS..108.4218Z .
3. Hofrichter MA, Nanda I, Gräf J, Schröder J, Shehata-Dieler W, Vona B, Haaf T . A Novel de novo Mutation in CEACAM16 Associated with Postlingual Hearing Impairment . Molecular Syndromology . 6 . 4 . 156–163 . October 2015 . 26648831 . 4662267 . 10.1159/000439576 .