CCR8 (gene) explained

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.^[1] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

Function

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.^[2] CCL8 also functions as a CCR8 agonist.^[3]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.

See also

• CC chemokine receptors

External links

• • Web site: Chemokine Receptors: CCR8 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-03 . 2008-06-07 . https://web.archive.org/web/20080607150553/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2234 . dead .

Further reading

• Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM . HIV-1 infection and chemokine receptor modulation . Curr. HIV Res. . 2 . 1 . 39–50 . 2004 . 15053339 . 10.2174/1570162043484997 .
• Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Santoni A . Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues . J. Immunol. . 157 . 7 . 2759–63 . 1996 . 10.4049/jimmunol.157.7.2759 . 8816377 . free .
• Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G . Molecular cloning and RNA expression of two new human chemokine receptor-like genes . Biochem. Biophys. Res. Commun. . 227 . 3 . 846–53 . 1996 . 8886020 . 10.1006/bbrc.1996.1595 .
• Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M . Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor . Eur. J. Immunol. . 26 . 12 . 3021–8 . 1996 . 8977299 . 10.1002/eji.1830261230 . 41090013 . free .
• Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM . Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309 . J. Exp. Med. . 186 . 1 . 165–70 . 1997 . 9207005 . 2198957 . 10.1084/jem.186.1.165 .
• Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B . Identification of CCR8, the receptor for the human CC chemokine I-309 . J. Biol. Chem. . 272 . 28 . 17251–4 . 1997 . 9211859 . 10.1074/jbc.272.28.17251 . free .
• Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S, Taub D, Samson M, Parmentier M, Rucker J, Doranz BJ, Doms RW . The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains . J. Biol. Chem. . 273 . 1 . 386–91 . 1998 . 9417093 . 10.1074/jbc.273.1.386 . free .
• Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G . Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3 . J. Immunol. . 160 . 4 . 1975–81 . 1998 . 10.4049/jimmunol.160.4.1975 . 9469461 . free .
• Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H . Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection . Biochem. Biophys. Res. Commun. . 243 . 2 . 497–502 . 1998 . 9480837 . 10.1006/bbrc.1998.8130 .
• Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A, Napolitano M . Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor . Eur. J. Immunol. . 28 . 2 . 582–8 . 1998 . 9521068 . 10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A . free .
• Zingoni A, Soto H, Hedrick JA, Stoppacciaro A, Storlazzi CT, Sinigaglia F, D'Ambrosio D, O'Garra A, Robinson D, Rocchi M, Santoni A, Zlotnik A, Napolitano M . The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells . J. Immunol. . 161 . 2 . 547–51 . 1998 . 10.4049/jimmunol.161.2.547 . 9670926 . free .
• Efremov R, Truong MJ, Darcissac EC, Zeng J, Grau O, Vergoten G, Debard C, Capron A, Bahr GM . Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function . Eur. J. Biochem. . 263 . 3 . 746–56 . 1999 . 10469138 . 10.1046/j.1432-1327.1999.00553.x . free .
• Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP . The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8 . Eur. J. Immunol. . 29 . 10 . 3210–5 . 1999 . 10540332 . 10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W . free .
• Lee S, Tiffany HL, King L, Murphy PM, Golding H, Zaitseva MB . CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor . J. Virol. . 74 . 15 . 6946–52 . 2000 . 10888633 . 112211 . 10.1128/JVI.74.15.6946-6952.2000 .
• Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ . LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8 . Blood . 96 . 3 . 840–5 . 2000 . 10910894 . 10.1182/blood.V96.3.840.
• Rosu-Myles M, Khandaker M, Wu DM, Keeney M, Foley SR, Howson-Jan K, Yee IC, Fellows F, Kelvin D, Bhatia M . Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny . Stem Cells . 18 . 5 . 374–81 . 2000 . 11007922 . 10.1634/stemcells.18-5-374 . 24126030 . free .
• Utaipat U, Duerr A, Rudolph DL, Yang C, Butera ST, Lupo D, Pisell T, Tangmunkongvorakul A, Kamtorn N, Nantachit N, Nagachinta T, Suriyanon V, Robison V, Nelson KE, Sittisombut N, Lal RB . Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives . AIDS Res. Hum. Retroviruses . 18 . 1 . 1–11 . 2002 . 11804551 . 10.1089/088922202753394664 .
• Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V, Romagnani P, Maggi E, Romagnani S . Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes . J. Exp. Med. . 196 . 3 . 379–87 . 2002 . 12163566 . 2193942 . 10.1084/jem.20020110 .
• Spinetti G, Bernardini G, Camarda G, Mangoni A, Santoni A, Capogrossi MC, Napolitano M . The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway . J. Leukoc. Biol. . 73 . 1 . 201–7 . 2003 . 12525579 . 10.1189/jlb.0302105 . 25301611 . free .

Notes and References

1. Web site: Entrez Gene: CCR8 chemokine (C-C motif) receptor 8.
2. Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP . The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8 . Eur. J. Immunol. . 29 . 10 . 3210–5 . October 1999 . 10540332 . 10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W . free .
3. Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD . Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells . Nat. Immunol. . 12 . 2 . 167–77 . 2011 . 21217759 . 3863381 . 10.1038/ni.1984 .