CDS2 explained

Phosphatidate cytidylyltransferase 2 is an enzyme that in humans is encoded by the CDS2 gene.^{[1] [2] [3]}

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.^{[4] [5]} and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (CDS1) and a second (this gene) to 20p13.^[6]

Further reading

• Lykidis A, Jackson PD, Rock CO, Jackowski S . The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content . The Journal of Biological Chemistry . 272 . 52 . 33402–9 . Dec 1997 . 9407135 . 10.1074/jbc.272.52.33402 . free .
• Halford S, Inglis S, Gwilliam R, Spencer P, Mohamed M, Ebenezer ND, Hunt DM . Genomic organization of human CDS2 and evaluation as a candidate gene for corneal hereditary endothelial dystrophy 2 on chromosome 20p13 . Experimental Eye Research . 75 . 5 . 619–23 . Nov 2002 . 12457874 . 10.1006/exer.2002.2052 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM . Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes . Genomics . 54 . 1 . 140–4 . Nov 1998 . 9806839 . 10.1006/geno.1998.5547 .
2. Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, Zuffardi O, Ballabio A, Banfi S, Franco B . Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene . Genomics . 55 . 1 . 68–77 . Jan 1999 . 9889000 . 10.1006/geno.1998.5610 .
3. Web site: Entrez Gene: CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2.
4. Nowicki M, Müller F, Frentzen M . Cardiolipin synthase of Arabidopsis thaliana . FEBS Letters . 579 . 10 . 2161–5 . Apr 2005 . 15811335 . 10.1016/j.febslet.2005.03.007 . 21937549 . free .
5. Nowicki M . Characterization of the Cardiolipin Synthase from Arabidopsis thaliana . Ph.D. Thesis, RWTH-Aachen University . 2006 . 2011-07-11 . https://web.archive.org/web/20111005093127/http://darwin.bth.rwth-aachen.de/opus/volltexte/2006/1629/ . 2011-10-05 . dead .
6. Web site: Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1.