CDS1 (gene) explained

Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.

Function

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin. and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.

Further reading

• Liu Y, Virshup DM, White RL, Hsu LC . Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha . Cancer Research . 62 . 22 . 6357–61 . November 2002 . 12438214 .
• Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, Zuffardi O, Ballabio A, Banfi S, Franco B . 6 . Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene . Genomics . 55 . 1 . 68–77 . January 1999 . 9889000 . 10.1006/geno.1998.5610 .
• Lykidis A, Jackson PD, Rock CO, Jackowski S . The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content . The Journal of Biological Chemistry . 272 . 52 . 33402–9 . December 1997 . 9407135 . 10.1074/jbc.272.52.33402 . free .
• Heacock AM, Uhler MD, Agranoff BW . Cloning of CDP-diacylglycerol synthase from a human neuronal cell line . Journal of Neurochemistry . 67 . 5 . 2200–3 . November 1996 . 8863531 . 10.1046/j.1471-4159.1996.67052200.x . 2805319 . 2027.42/65959 . free .