CDP-paratose synthase explained

CDP-paratose synthase
Ec Number:	1.1.1.342

CDP-paratose synthase (rfbS (gene)) is an enzyme with systematic name CDP-alpha-D-paratose:NADP⁺ 4-oxidoreductase.^{[1] [2]} This enzyme catalyses the following chemical reaction

CDP-alpha-D-paratose + NADP⁺

\rightleftharpoons CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H⁺

This enzyme participates in synthesis of paratose and tyvelose.

Notes and References

1. Verma N, Reeves P . Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae . Journal of Bacteriology . 171 . 10 . 5694–701 . October 1989 . 2793833 . 210416 .
2. Hallis TM, Lei Y, Que NL, Liu H . Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase . Biochemistry . 37 . 14 . 4935–45 . April 1998 . 9538012 . 10.1021/bi9725529 .