CDP-glucose 4,6-dehydratase explained

CDP-glucose 4,6-dehydratase
Ec Number:	4.2.1.45
Cas Number:	37259-55-5
Go Code:	0047733

The enzyme CDP-glucose 4,6-dehydratase catalyzes the chemical reaction

\rightleftharpoons CDP-4-dehydro-6-deoxy-D-glucose + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD⁺.

Nomenclature

The systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include:

• cytidine diphosphoglucose oxidoreductase, and
• CDP-glucose 4,6-hydro-lyase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• Hey AE, Elbein AD . 1966 . Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase . J. Biol. Chem. . 241 . 5473 - 8 . 4380946 . 22 .
• Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL . 1966 . Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3 Cytidine diphosphate D-glucose oxidoreductase . J. Biol. Chem. . 241 . 4283 - 7 . 4288651 . 18 .
• Melo A, Elliott WH, Glaser L . 1968 . The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase . J. Biol. Chem. . 243 . 1467 - 74 . 4869560 . 7 .