CDP-4-dehydro-6-deoxyglucose reductase explained

CDP-4-dehydro-6-deoxyglucose reductase
Ec Number:	1.17.1.1
Cas Number:	37256-87-4
Go Code:	0047099

CDP-4-dehydro-6-deoxyglucose reductase is an enzyme that catalyzes the chemical reaction

CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)⁺ + H₂O

\rightleftharpoons

CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H⁺

The 4 substrates of this enzyme are CDP-4-dehydro-3,6-dideoxy-D-glucose, nicotinamide adenine dinucleotide ion, nicotinamide adenine dinucleotide phosphate ion, and water, whereas its 4 products are CDP-4-dehydro-6-deoxy-D-glucose, nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)⁺ 3-oxidoreductase. Other names in common use include CDP-4-keto-6-deoxyglucose reductase, cytidine diphospho-4-keto-6-deoxy-D-glucose reductase, cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase, CDP-4-keto-deoxy-glucose reductase, CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system, and NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase. This enzyme participates in starch and sucrose metabolism.

References

Pape H, Strominger JL . 1969 . Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V. Partial purification of the two protein components required for introduction of the 3-deoxy group . J. Biol. Chem. . 244 . 3598 - 604 . 4389672 . 13 .
Rubenstein PA, Strominger JL . 1974 . Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8. Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose . J. Biol. Chem. . 249 . 3776 - 81 . 4152100 . 12 .
Liu HW, Thorson JS . 1994 . Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria . Annu. Rev. Microbiol. . 48 . 1 . 223 - 56 . 7826006 . 10.1146/annurev.mi.48.100194.001255 .