CDKL2 explained

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.^{[1] [2]}

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.^[2]

Further reading

• Marracci GH . Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck) . Biochem. Biophys. Res. Commun. . 344 . 3 . 963–971 . 2006 . 16631599 . 10.1016/j.bbrc.2006.03.172 . vanc. Marquardt WE . Strehlow A . 3 . McKeon . G . Gross . J . Buck . D . Kozell . L . Bourdette . D .
• Sarkar SN . Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling . Nat. Struct. Mol. Biol. . 11 . 11 . 1060–1067 . 2004 . 15502848 . 10.1038/nsmb847 . vanc. Peters KL . Elco CP . 3 . Sakamoto . Shuji . Pal . Srabani . Sen . Ganes C . 6869429 .
• Tao J . Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation . Am. J. Hum. Genet. . 75 . 6 . 1149–1154 . 2005 . 15499549 . 10.1086/426460 . 1182152 . vanc. Van Esch H . Hagedorn-Greiwe M . 3 . Hoffmann . Kirsten . Moser . Bettina . Raynaud . Martine . Sperner . Jürgen . Fryns . Jean-Pierre . Schwinger . Eberhard .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
• Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC . Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors . J. Biol. Chem. . 270 . 16 . 9115–9120 . 1995 . 7721825 . 10.1074/jbc.270.16.9115 . free .

Notes and References

1. Taglienti CA, Wysk M, Davis RJ . Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE . Oncogene . 13 . 12 . 2563–74 . Feb 1997 . 9000130 .
2. Web site: Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase).