CDK5RAP3 explained

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.^{[1] [2]}

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.^[2]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Wang X, Ching YP, Lam WH . Identification of a common protein association region in the neuronal Cdk5 activator . J. Biol. Chem. . 275 . 41 . 31763–9 . 2000 . 10915792 . 10.1074/jbc.M004358200 . etal. free .
• Ching YP, Pang AS, Lam WH . Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor . J. Biol. Chem. . 277 . 18 . 15237–40 . 2002 . 11882646 . 10.1074/jbc.C200032200 . etal. free .
• Chen J, Liu B, Liu Y . A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart . Biochem. Biophys. Res. Commun. . 294 . 1 . 161–6 . 2002 . 12054757 . 10.1016/S0006-291X(02)00446-1 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Xie YH, He XH, Tang YT . Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein . Cell Res. . 13 . 2 . 83–91 . 2003 . 12737517 . 10.1038/sj.cr.7290153 . 22264922 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Cen H, Zheng S, Fang YM . Induction of HSF1 expression is associated with sporadic colorectal cancer . World J. Gastroenterol. . 10 . 21 . 3122–6 . 2004 . 15457556 . 10.3748/wjg.v10.i21.3122. 4611254 . etal . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Jiang H, Luo S, Li H . Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint . J. Biol. Chem. . 280 . 21 . 20651–9 . 2005 . 15790566 . 10.1074/jbc.M413431200 . free .
• Yin X, Warner DR, Roberts EA . Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 . Int. J. Mol. Med. . 16 . 2 . 251–6 . 2005 . 16012757 . 10.3892/ijmm.16.2.251. etal.
• Wang J, He X, Luo Y, Yarbrough WG . A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2 . Biochem. J. . 393 . Pt 2 . 489–501 . 2006 . 16173922 . 10.1042/BJ20050960 . 1360699 .
• Kim E, Chen F, Wang CC, Harrison LE . CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation . Int. J. Oncol. . 28 . 1 . 191–4 . 2006 . 16327995 . 10.3892/ijo.28.1.191.
• Camargo LM, Collura V, Rain JC . Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia . Mol. Psychiatry . 12 . 1 . 74–86 . 2007 . 17043677 . 10.1038/sj.mp.4001880 . etal. 25119660 .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
• Stav D, Bar I, Sandbank J . Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma . Int. J. Biol. Markers . 22 . 2 . 108–13 . 2007 . 17549666 . 10.5301/jbm.2008.3142.
• Wang J, An H, Mayo MW . LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB . Cancer Cell . 12 . 3 . 239–51 . 2007 . 17785205 . 10.1016/j.ccr.2007.07.002 . etal. free .

Notes and References

1. Ching YP, Qi Z, Wang JH . Cloning of three novel neuronal Cdk5 activator binding proteins . Gene . 242 . 1–2 . 285–94 . Apr 2000 . 10721722 . 10.1016/S0378-1119(99)00499-0 .
2. Web site: Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3.