PCTK1 explained

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the CDK16 gene.^{[1] [2]}

Function

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.

Interactions

PCTK1 has been shown to interact with CDK5R1.^[3]

Further reading

• Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH . A family of human cdc2-related protein kinases . EMBO J. . 11 . 8 . 2909–17 . 1992 . 1639063 . 556772 . 10.1002/j.1460-2075.1992.tb05360.x.
• Knight JC, Renwick PJ, Downing JR, Okuda T . Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3 . Cytogenet. Cell Genet. . 71 . 2 . 155–7 . 1995 . 7656587 . 10.1159/000134097 .
• Okuda T, Valentine VA, Shapiro DN, Downing JR . Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes . Genomics . 21 . 1 . 217–21 . 1994 . 8088790 . 10.1006/geno.1994.1245 .
• Carrel L, Clemson CM, Dunn JM, Miller AP, Hunt PA, Lawrence JB, Willard HF . X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse . Hum. Mol. Genet. . 5 . 3 . 391–401 . 1996 . 8852665 . 10.1093/hmg/5.3.391 . free .
• Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F . The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins . Mol. Gen. Genet. . 254 . 5 . 571–7 . 1997 . 9197417 . 10.1007/s004380050453 . 22809140 .
• Esposito T, Gianfrancesco F, Ciccodicola A, D'Esposito M, Nagaraja R, Mazzarella R, D'Urso M, Forabosco A . Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E . Genomics . 43 . 2 . 183–90 . 1997 . 9244435 . 10.1006/geno.1997.4797 .
• Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R . The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression . J. Biol. Chem. . 273 . 39 . 25388–92 . 1998 . 9738006 . 10.1074/jbc.273.39.25388 . free .
• Le Bouffant F, Capdevielle J, Guillemot JC, Sladeczek F . Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins . Eur. J. Biochem. . 257 . 1 . 112–20 . 1998 . 9799109 . 10.1046/j.1432-1327.1998.2570112.x . free .
• Besset V, Rhee K, Wolgemuth DJ . The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation . Cell Growth Differ. . 10 . 3 . 173–81 . 1999 . 10099831 .
• Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY . Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35 . J. Biol. Chem. . 277 . 35 . 31988–93 . 2002 . 12084709 . 10.1074/jbc.M201161200 . free .
• Graeser R, Gannon J, Poon RY, Dubois T, Aitken A, Hunt T . Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells . J. Cell Sci. . 115 . Pt 17 . 3479–90 . 2002 . 10.1242/jcs.115.17.3479 . 12154078 .
• Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F . Protein profile of tax-associated complexes . J. Biol. Chem. . 279 . 1 . 495–508 . 2004 . 14530271 . 10.1074/jbc.M310069200 . free .
• Palmer KJ, Konkel JE, Stephens DJ . PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport . J. Cell Sci. . 118 . Pt 17 . 3839–47 . 2005 . 16091426 . 10.1242/jcs.02496 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Liu Y, Cheng K, Gong K, Fu AK, Ip NY . Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis . J. Biol. Chem. . 281 . 15 . 9852–8 . 2006 . 16461345 . 10.1074/jbc.M513496200 . free .

Notes and References

1. Okuda T, Cleveland JL, Downing JR . PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family . Oncogene . 7 . 11 . 2249–58 . Dec 1992 . 1437147 .
2. Web site: Entrez Gene: PCTK1 PCTAIRE protein kinase 1.
3. Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY . Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35 . J. Biol. Chem. . 277 . 35 . 31988–93 . Aug 2002 . 12084709 . 10.1074/jbc.M201161200 . free .