Cyclin-dependent kinase 10 explained

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.^[3]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.^[4]

Further reading

• Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A . The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle . Cancer Res. . 55 . 18 . 3992–5 . 1995 . 7664269 .
• Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Heubner K, Croce CM . Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer . Cancer Res. . 55 . 6 . 1199–205 . 1995 . 7882308 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Crawford J, Ianzano L, Savino M, Whitmore S, Cleton-Jansen AM, Settasatian C, d'apolito M, Seshadri R, Pronk JC, Auerbach AD, Verlander PC, Mathew CG, Tipping AJ, Doggett NA, Zelante L, Callen DF, Savoia A . The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer . Genomics . 56 . 1 . 90–7 . 1999 . 10036189 . 10.1006/geno.1998.5676 .
• Sergère JC, Thuret JY, Le Roux G, Carosella ED, Leteurtre F . Human CDK10 gene isoforms . Biochem. Biophys. Res. Commun. . 276 . 1 . 271–7 . 2000 . 11006117 . 10.1006/bbrc.2000.3395 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Kasten M, Giordano A . Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity . Oncogene . 20 . 15 . 1832–8 . 2001 . 11313931 . 10.1038/sj.onc.1204295 . 22792083 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415-8 . 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry . Mol. Cell. Proteomics . 6 . 3 . 537–47 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . free . 10033/19756 . free .

Notes and References

1. Graña X, Claudio PP, De Luca A, Sang N, Giordano A . PISSLRE, a human novel CDC2-related protein kinase . Oncogene . 9 . 7 . 2097–103 . Jul 1994 . 8208557 .
2. Brambilla R, Draetta G . Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases . Oncogene . 9 . 10 . 3037–41 . Oct 1994 . 8084611 .
3. Web site: Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10.
4. Kasten M, Giordano A . Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity . Oncogene . 20 . 15 . 1832–8 . Apr 2001 . 11313931 . 10.1038/sj.onc.1204295 . 22792083 .