CDIPT explained

CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.^{[1] [2]}

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of multiple G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.

Further reading

• Antonsson B . Phosphatidylinositol synthase from mammalian tissues . Biochim. Biophys. Acta . 1348 . 1–2 . 179–86 . 1997 . 9370331 . 10.1016/s0005-2760(97)00105-7.
• Antonsson BE . Purification and characterization of phosphatidylinositol synthase from human placenta . Biochem. J. . 297 . Pt 3. 517–22 . 1994 . 8110188 . 10.1042/bj2970517. 1137864 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Bouwmeester T . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . vanc. Bauch A . Ruffner H . 3 . Angrand . Pierre-Olivier . Bergamini . Giovanna . Croughton . Karen . Cruciat . Cristina . Eberhard . Dirk . Gagneur . Julien . 11683986 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• de Serres FJ . Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles . Monaldi Archives for Chest Disease . 63 . 3 . 133–41 . 2005 . 16312203 . 10.4081/monaldi.2005.630. vanc. Luisetti M . Ferrarotti I . 3 . Blanco . I . Fernández-Bustillo . E . free.

Notes and References

1. Lykidis A, Jackson PD, Rock CO, Jackowski S . The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content . J Biol Chem . 272 . 52 . 33402–9 . Jan 1998 . 9407135 . 10.1074/jbc.272.52.33402 . free .
2. Web site: Entrez Gene: CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase).