CDH9 explained

Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.^{[1] [2]}

Clinical significance

An association with autism has been suggested.^[3]

See also

• Cadherin
• Heritability of autism

Further reading

• Nollet F, Kools P, van Roy F . Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members . Journal of Molecular Biology . 299 . 3 . 551–72 . June 2000 . 10835267 . 10.1006/jmbi.2000.3777 .
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M . Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins . The Biochemical Journal . 349 . Pt 1 . 159–67 . July 2000 . 10861224 . 1221133 . 10.1042/0264-6021:3490159 .
• Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, Berrettini W, Hakonarson H . A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa . Molecular Psychiatry . 16 . 9 . 949–59 . September 2011 . 21079607 . 3859494 . 10.1038/mp.2010.107 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Ali J, Liao F, Martens E, Muller WA . Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion . Microcirculation . 4 . 2 . 267–77 . June 1997 . 9219219 . 10.3109/10739689709146790 . 21501093 .
• Thedieck C, Kalbacher H, Kuczyk M, Müller GA, Müller CA, Klein G . Cadherin-9 is a novel cell surface marker for the heterogeneous pool of renal fibroblasts . PLOS ONE . 2 . 7 . e657 . 2007 . 17668045 . 1924602 . 10.1371/journal.pone.0000657 . 2007PLoSO...2..657T . Zoccali . Carmine . free .
• Hülsken J, Birchmeier W, Behrens J . E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton . The Journal of Cell Biology . 127 . 6 Pt 2 . 2061–9 . December 1994 . 7806582 . 2120290 . 10.1083/jcb.127.6.2061 .

Notes and References

1. Web site: Entrez Gene: cadherin 9.
2. Suzuki S, Sano K, Tanihara H . Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue . Cell Regulation . 2 . 4 . 261–70 . April 1991 . 2059658 . 361775 . 10.1091/mbc.2.4.261 .
3. Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, Salyakina D, Imielinski M, Bradfield JP, Sleiman PM, Kim CE, Hou C, Frackelton E, Chiavacci R, Takahashi N, Sakurai T, Rappaport E, Lajonchere CM, Munson J, Estes A, Korvatska O, Piven J, Sonnenblick LI, Alvarez Retuerto AI, Herman EI, Dong H, Hutman T, Sigman M, Ozonoff S, Klin A, Owley T, Sweeney JA, Brune CW, Cantor RM, Bernier R, Gilbert JR, Cuccaro ML, McMahon WM, Miller J, State MW, Wassink TH, Coon H, Levy SE, Schultz RT, Nurnberger JI, Haines JL, Sutcliffe JS, Cook EH, Minshew NJ, Buxbaum JD, Dawson G, Grant SF, Geschwind DH, Pericak-Vance MA, Schellenberg GD, Hakonarson H . 6 . Common genetic variants on 5p14.1 associate with autism spectrum disorders . Nature . 459 . 7246 . 528–33 . May 2009 . 19404256 . 2943511 . 10.1038/nature07999 . 2009Natur.459..528W .