CDH6 explained

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.^{[1] [2] [3]}

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.

Further reading

• MacCalman CD, Getsios S, Chen GT . Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation. . Am. J. Reprod. Immunol. . 39 . 2 . 96–107 . 1998 . 9506208 . 10.1111/j.1600-0897.1998.tb00341.x. 23871813 .
• Suzuki S, Sano K, Tanihara H . Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. . Cell Regul. . 2 . 4 . 261–70 . 1991 . 2059658 . 10.1091/mbc.2.4.261. 361775 .
• Paul R, Ewing CM, Robinson JC . Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. . Cancer Res. . 57 . 13 . 2741–8 . 1997 . 9205085 . etal.
• Getsios S, Chen GT, Stephenson MD . Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. . Dev. Dyn. . 211 . 3 . 238–47 . 1998 . 9520111 . 10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I . etal. 43022919 .
• Kremmidiotis G, Baker E, Crawford J . Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. . Genomics . 49 . 3 . 467–71 . 1998 . 9615235 . 10.1006/geno.1998.5281 . etal.
• Shimoyama Y, Takeda H, Yoshihara S . Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin. . J. Biol. Chem. . 274 . 17 . 11987–94 . 1999 . 10207020 . 10.1074/jbc.274.17.11987 . etal. free .
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M . Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. . Biochem. J. . 349 . Pt 1 . 159–67 . 2001 . 10861224 . 10.1042/0264-6021:3490159 . 1221133 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Liu T, Qian WJ, Gritsenko MA . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.

Notes and References

1. Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S . Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells . Cancer Res . 55 . 10 . 2206–11 . June 1995 . 7743525 .
2. Chalmers IJ, Hofler H, Atkinson MJ . Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma . Genomics . 57 . 1 . 160–3 . June 1999 . 10191097 . 10.1006/geno.1998.5717 .
3. Web site: Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney).