CDH17 explained

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.^{[1] [2] [3]}

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.^[4]

Further reading

• Gessner R, Tauber R . Intestinal cell adhesion molecules. Liver-intestine cadherin. . Ann. N. Y. Acad. Sci. . 915 . 136–43 . 2001 . 11193569 . 10.1111/j.1749-6632.2000.tb05236.x . 27317315 .
• Gilston A . Reducing the hazard of disconnected tubes. . Anaesthesia . 32 . 9 . 922 . 1978 . 603017 . 10.1111/j.1365-2044.1977.tb10133.x . 31703359 . free .
• Dantzig AH, Hoskins JA, Tabas LB . Association of intestinal peptide transport with a protein related to the cadherin superfamily. . Science . 264 . 5157 . 430–3 . 1994 . 8153632 . 10.1126/science.8153632 . 1994Sci...264..430D . etal.
• Suzuki Y, Tsunoda T, Sese J . Identification and characterization of the potential promoter regions of 1031 kinds of human genes. . Genome Res. . 11 . 5 . 677–84 . 2001 . 11337467 . 10.1101/gr.gr-1640r. 311086 . etal.
• Grötzinger C, Kneifel J, Patschan D . LI-cadherin: a marker of gastric metaplasia and neoplasia. . Gut . 49 . 1 . 73–81 . 2001 . 11413113 . 10.1136/gut.49.1.73 . 1728355 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Takamura M, Sakamoto M, Ino Y . Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. . Cancer Sci. . 94 . 5 . 425–30 . 2003 . 12824888 . 10.1111/j.1349-7006.2003.tb01459.x . 25229564 . etal. free . 11160223 .
• Wendeler MW, Praus M, Jung R . Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. . Exp. Cell Res. . 294 . 2 . 345–55 . 2004 . 15023525 . 10.1016/j.yexcr.2003.11.022 . etal.
• Ko S, Chu KM, Luk JM . Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. . Biochem. Biophys. Res. Commun. . 319 . 2 . 562–8 . 2004 . 15178443 . 10.1016/j.bbrc.2004.04.197 . etal.
• Takamura M, Ichida T, Matsuda Y . Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. . Cancer Lett. . 212 . 2 . 253–9 . 2004 . 15279905 . 10.1016/j.canlet.2004.03.016 . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . etal. free .
• Wang XQ, Luk JM, Leung PP . Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma. . Clin. Cancer Res. . 11 . 2 Pt 1 . 483–9 . 2005 . 10.1158/1078-0432.483.11.2 . 15701831 . etal. free .
• Wang XQ, Luk JM, Garcia-Barcelo M . Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma. . Clin. Cancer Res. . 12 . 17 . 5248–52 . 2007 . 16951245 . 10.1158/1078-0432.CCR-06-0558 . etal. 22423581 .

Notes and References

1. Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF . Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity . Genomics . 49 . 3 . 467–71 . Aug 1998 . 9615235 . 10.1006/geno.1998.5281 .
2. Chalmers IJ, Hofler H, Atkinson MJ . Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma . Genomics . 57 . 1 . 160–3 . Jun 1999 . 10191097 . 10.1006/geno.1998.5717 .
3. Web site: Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine).
4. Web site: Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine).