CDH15 explained

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.^{[1] [2]}

Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.^[2]

Interactions

CDH15 has been shown to interact with ARVCF.^[3]

References

Further reading

• Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A . Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. . Proc. Natl. Acad. Sci. U.S.A. . 88 . 18 . 8024–8 . 1991 . 1840697 . 52438 . 10.1073/pnas.88.18.8024 . 1991PNAS...88.8024D . free .
• Bornemann A, Schmalbruch H . Immunocytochemistry of M-cadherin in mature and regenerating rat muscle. . Anat. Rec. . 239 . 2 . 119–25 . 1994 . 8059975 . 10.1002/ar.1092390202 . 43526913 .
• Shibata T, Shimoyama Y, Gotoh M, Hirohashi S . Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. . J. Biol. Chem. . 272 . 8 . 5236–40 . 1997 . 9030594 . 10.1074/jbc.272.8.5236 . free .
• Kuch C, Winnekendonk D, Butz S, Unvericht U, Kemler R, Starzinski-Powitz A . M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells. . Exp. Cell Res. . 232 . 2 . 331–8 . 1997 . 9168809 . 10.1006/excr.1997.3519 .
• Shimoyama Y, Shibata T, Kitajima M, Hirohashi S . Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin. . J. Biol. Chem. . 273 . 16 . 10011–8 . 1998 . 9545347 . 10.1074/jbc.273.16.10011 . free .
• Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF . Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. . Genomics . 49 . 3 . 467–71 . 1998 . 9615235 . 10.1006/geno.1998.5281 .
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M . Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. . Biochem. J. . 349 . Pt 1 . 159–67 . 2001 . 10861224 . 1221133 . 10.1042/0264-6021:3490159 .
• Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A . The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. . J. Cell Sci. . 113 . 22 . 4121–35 . 2001 . 10.1242/jcs.113.22.4121 . 11058098 .
• Meigs TE, Fields TA, McKee DD, Casey PJ . Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 2 . 519–24 . 2001 . 11136230 . 14619 . 10.1073/pnas.021350998 . free .
• Hollnagel A, Grund C, Franke WW, Arnold HH . The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. . Mol. Cell. Biol. . 22 . 13 . 4760–70 . 2002 . 12052883 . 133893 . 10.1128/MCB.22.13.4760-4770.2002 .
• Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS . Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 7 . 3989–94 . 2003 . 12634428 . 153035 . 10.1073/pnas.0736565100 . 2003PNAS..100.3989K . free .

Notes and References

1. Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A . The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species . Genomics . 14 . 2 . 488–90 . December 1992 . 1427864 . 10.1016/S0888-7543(05)80247-2 .
2. Web site: Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule).
3. Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A . The armadillo repeat region targets ARVCF to cadherin-based cellular junctions . J. Cell Sci. . 113 . 22 . 4121–35 . November 2000 . 10.1242/jcs.113.22.4121 . 11058098 .