CDH10 explained

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.^{[1] [2]}

Clinical significance

An association with autism has been suggested.^[3]

See also

• Cadherin
• Heritability of autism

Further reading

• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rose JE, Behm FM, Drgon T . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. . Mol. Med. . 16 . 7–8 . 247–53 . 2010. 20379614 . 10.2119/molmed.2009.00159 . 2896464. etal.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M . Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. . Biochem. J. . 349 . Pt 1 . 159–67 . 2000 . 10861224 . 10.1042/0264-6021:3490159 . 1221133.
• Wang K, Zhang H, Ma D . Common genetic variants on 5p14.1 associate with autism spectrum disorders. . Nature . 459 . 7246 . 528–33 . 2009 . 19404256 . 10.1038/nature07999 . 2943511. 2009Natur.459..528W . etal.
• Potkin SG, Guffanti G, Lakatos A . Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. . PLOS ONE . 4 . 8 . e6501 . 2009 . 19668339 . 10.1371/journal.pone.0006501 . 2719581. 2009PLoSO...4.6501P . etal. free .
• Gil OD, Needleman L, Huntley GW . Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex. . J. Comp. Neurol. . 453 . 4 . 372–88 . 2002 . 12389209 . 10.1002/cne.10424 . 25610258 .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129. etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Kools P, Vanhalst K, Van den Eynde E, van Roy F . The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14. . FEBS Lett. . 452 . 3 . 328–34 . 1999 . 10386616 . 10.1016/S0014-5793(99)00672-9. 44714251 . free .
• Hillier LD, Lennon G, Becker M . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1996 . 8889549 . 10.1101/gr.6.9.807. etal. free .
• Ali J, Liao F, Martens E, Muller WA . Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. . Microcirculation . 4 . 2 . 267–77 . 1997 . 9219219 . 10.3109/10739689709146790. 21501093 .
• Ma D, Salyakina D, Jaworski JM . A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. . Ann. Hum. Genet. . 73 . Pt 3 . 263–73 . 2009 . 19456320 . 10.1111/j.1469-1809.2009.00523.x . 2918410. etal.
• Hülsken J, Birchmeier W, Behrens J . E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. . J. Cell Biol. . 127 . 6 Pt 2 . 2061–9 . 1994 . 7806582 . 10.1083/jcb.127.6.2061. 2120290.

Notes and References

1. Web site: Entrez Gene: cadherin 10.
2. Suzuki S, Sano K, Tanihara H . Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue . Cell Regul. . 2 . 4 . 261–70 . April 1991 . 2059658 . 361775 . 10.1091/mbc.2.4.261.
3. Wang K, Zhang H, Ma D . Common genetic variants on 5p14.1 associate with autism spectrum disorders . Nature . 459 . 7246 . 528–33 . May 2009 . 19404256 . 2943511 . 10.1038/nature07999 . 2009Natur.459..528W . etal.