CDCA5 explained

WP:SE

Sororin is a protein that in humans is encoded by the CDCA5 gene.^{[1] [2] [3]}

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.^[4]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.^[5]

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Schmitz J, Watrin E, Lénárt P . Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. . Curr. Biol. . 17 . 7 . 630–6 . 2007 . 17349791 . 10.1016/j.cub.2007.02.029 . 2007CBio...17..630S . etal. 21.11116/0000-0002-101C-D . 11988060 . free .
• Díaz-Martínez LA, Giménez-Abián JF, Clarke DJ . Regulation of centromeric cohesion by sororin independently of the APC/C. . Cell Cycle . 6 . 6 . 714–24 . 2007 . 17361102 . 10.4161/cc.6.6.3935 . free .

Notes and References

1. Walker MG . Drug target discovery by gene expression analysis: cell cycle genes . Curr Cancer Drug Targets . 1 . 1 . 73–83 . Aug 2002 . 12188893 . 10.2174/1568009013334241 .
2. Rankin S, Ayad NG, Kirschner MW . Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates . Mol Cell . 18 . 2 . 185–200 . Apr 2005 . 15837422 . 10.1016/j.molcel.2005.03.017 . free .
3. Web site: Entrez Gene: CDCA5 cell division cycle associated 5.
4. Schmitz . J. . Watrin . E. . Lénárt . P. . Mechtler . K. . Peters . JM. . Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. . Curr Biol . 17 . 7 . 630–6 . Apr 2007 . 10.1016/j.cub.2007.02.029 . 17349791 . 2007CBio...17..630S . 21.11116/0000-0002-101C-D . 11988060 . free .
5. Nguyen . MH. . Koinuma . J. . Ueda . K. . Ito . T. . Tsuchiya . E. . Nakamura . Y. . Daigo . Y. . Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. . Cancer Res . 70 . 13 . 5337–47 . Jul 2010 . 10.1158/0008-5472.CAN-09-4372 . 20551060 . free .