CDC42EP4 explained

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.^{[1] [2] [3]}

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.^[3]

Further reading

• Osada N, Kusuda J, Suzuki Y . Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue. . J. Hum. Genet. . 45 . 6 . 374–7 . 2001 . 11185749 . 10.1007/s100380070012 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Blackshaw S, Harpavat S, Trimarchi J . Genomic analysis of mouse retinal development. . PLOS Biol. . 2 . 9 . E247 . 2006 . 15226823 . 10.1371/journal.pbio.0020247 . 439783 . etal . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Barrios-Rodiles M, Brown KR, Ozdamar B . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Hirsch DS, Pirone DM, Burbelo PD . A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes . J Biol Chem . 276 . 2 . 875–83 . Mar 2001 . 11035016 . 10.1074/jbc.M007039200 . free .
2. Joberty G, Perlungher RR, Macara IG . The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins . Mol Cell Biol . 19 . 10 . 6585–97 . Feb 2000 . 10490598 . 84628 . 10.1128/MCB.19.10.6585.
3. Web site: Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4.