CDC42EP2 explained

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.^{[1] [2] [3]}

Function

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.

Interactions

CDC42EP2 has been shown to interact with CDC42 and RHOQ.^[1]

Further reading

• Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC . A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus . Genome Research . 7 . 7 . 725–35 . Jul 1997 . 9253601 . 310681 . 10.1101/gr.7.7.725 .
• Burbelo PD, Snow DM, Bahou W, Spiegel S . MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts . Proceedings of the National Academy of Sciences of the United States of America . 96 . 16 . 9083–8 . Aug 1999 . 10430899 . 17736 . 10.1073/pnas.96.16.9083 . free . 1999PNAS...96.9083B .
• Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG . Borg proteins control septin organization and are negatively regulated by Cdc42 . Nature Cell Biology . 3 . 10 . 861–6 . Oct 2001 . 11584266 . 10.1038/ncb1001-861 . 58805 .
• Xue Y, Bi F, Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D . Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation . International Journal of Cancer . 118 . 12 . 2965–72 . Jun 2006 . 16395716 . 10.1002/ijc.21763 . 39137777 . free .

Notes and References

1. Joberty G, Perlungher RR, Macara IG . The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins . Molecular and Cellular Biology . 19 . 10 . 6585–97 . Oct 1999 . 10490598 . 84628 . 10.1128/MCB.19.10.6585.
2. Hirsch DS, Pirone DM, Burbelo PD . A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes . The Journal of Biological Chemistry . 276 . 2 . 875–83 . Jan 2001 . 11035016 . 10.1074/jbc.M007039200 . free .
3. Web site: Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2.