CDC42EP1 explained

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.^{[1] [2] [3]}

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Joberty G, Perlungher RR, Macara IG . The Borgs, a New Family of Cdc42 and TC10 GTPase-Interacting Proteins . Mol. Cell. Biol. . 19 . 10 . 6585–97 . 2000 . 10490598 . 10.1128/MCB.19.10.6585. 84628 .
• Dunham I . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . vanc. Shimizu N . Roe BA . 3 . Bruskiewich . R. . Beare . D. M. . Clamp . M. . Smink . L. J. . Ainscough . R. . Almeida . J. P. . 1999Natur.402..489D . free .
• Hirsch DS, Pirone DM, Burbelo PD . A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes . J. Biol. Chem. . 276 . 2 . 875–83 . 2001 . 11035016 . 10.1074/jbc.M007039200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gevaert K . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . vanc. Goethals M . Martens L . 3 . Van Damme . Jozef . Staes . An . Thomas . Grégoire R. . Vandekerckhove . Joël . 23783563 .
• Ballif BA . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . vanc. Villén J . Beausoleil SA . 3 . Schwartz . D . Gygi . SP . free .
• Collins JE . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . vanc. Wright CL . Edwards CA . 3 . Davis . Matthew P . Grinham . James A . Cole . Charlotte G . Goward . Melanie E . Aguado . Begoña . Mallya . Meera . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Zhang J . Cdc42 and RhoB Activation Are Required for Mannose Receptor-mediated Phagocytosis by Human Alveolar Macrophages . Mol. Biol. Cell . 16 . 2 . 824–34 . 2005 . 15574879 . 10.1091/mbc.E04-06-0463 . 545914 . vanc. Zhu J . Bu X . 3 . Cushion . M . Kinane . TB . Avraham . H . Koziel . H .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . free .

Notes and References

1. Bahou WF, Campbell AD, Wicha MS . cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression . J Biol Chem . 267 . 20 . 13986–92 . Aug 1992 . 10.1016/S0021-9258(19)49667-1 . 1629197 . free .
2. Burbelo PD, Snow DM, Bahou W, Spiegel S . MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts . Proc Natl Acad Sci U S A . 96 . 16 . 9083–8 . Sep 1999 . 10430899 . 17736 . 10.1073/pnas.96.16.9083 . 1999PNAS...96.9083B . free .
3. Web site: Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1.