CDC40 explained

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.^{[1] [2] [3]}

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.

Further reading

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• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Salcini AE, Confalonieri S, Doria M . Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module . Genes Dev. . 11 . 17 . 2239–49 . 1997 . 9303539 . 10.1101/gad.11.17.2239 . 275390 . etal.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Zhou Z, Reed R . Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing . EMBO J. . 17 . 7 . 2095–106 . 1998 . 9524131 . 10.1093/emboj/17.7.2095 . 1170554 .
• Ben-Yehuda S, Dix I, Russell CS . Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae . Genetics . 156 . 4 . 1503–17 . 2001 . 10.1093/genetics/156.4.1503 . 11102353 . 1461362 . etal.
• Jurica MS, Licklider LJ, Gygi SR . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 10.1017/S1355838202021088 . 1370266 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Barrios-Rodiles M, Brown KR, Ozdamar B . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M . Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control . RNA . 4 . 10 . 1304–12 . Oct 1998 . 9769104 . 1369702 . 10.1017/S1355838298980712 .
2. Lindsey LA, Garcia-Blanco MA . Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p . J Biol Chem . 273 . 49 . 32771–5 . Jan 1999 . 9830021 . 10.1074/jbc.273.49.32771 . free .
3. Web site: Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae).