CDC25C explained

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.^[1]

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.^[2]

Interactions

CDC25C has been shown to interact with MAPK14,^[3] CHEK1,^[4] PCNA,^[5] PIN1,^{[6] [7] [8]} PLK3^[9] and NEDD4.^[8]

See also

• Cdc25

Further reading

• Draetta G, Eckstein J . Cdc25 protein phosphatases in cell proliferation. . Biochim. Biophys. Acta . 1332 . 2 . M53–63 . 1997 . 9141461 . 10.1016/S0304-419X(96)00049-2.
• Book: Nilsson I, Hoffmann I . Cell cycle regulation by the Cdc25 phosphatase family . Progress in Cell Cycle Research . 4 . 107–14 . 2000 . 10740819 . 10.1007/978-1-4615-4253-7_10. 978-1-4613-6909-7 .
• Amini S, Khalili K, Sawaya BE . Effect of HIV-1 Vpr on cell cycle regulators. . DNA Cell Biol. . 23 . 4 . 249–60 . 2004 . 15142382 . 10.1089/104454904773819833 .
• Kino T, Chrousos GP . Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? . Ann. N. Y. Acad. Sci. . 1024 . 1. 153–67 . 2004 . 15265780 . 10.1196/annals.1321.013 . 2004NYASA1024..153K . 23655886 .
• Andersen JL, Planelles V . The role of Vpr in HIV-1 pathogenesis. . Curr. HIV Res. . 3 . 1 . 43–51 . 2005 . 15638722 . 10.2174/1570162052772988 .
• Sartor H . Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively . Genomics . 13 . 3 . 911–2 . 1992 . 1386342 . 10.1016/0888-7543(92)90190-4 . Ehlert F . Grzeschik KH . 3 . Mu¨Ller . Rolf . Adolph . Sabine .
• Strausfeld U . Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein . Nature . 351 . 6323 . 242–5 . 1991 . 1828290 . 10.1038/351242a0 . Labbé JC . Fesquet D . 3 . Cavadore . J. C. . Picard . A. . Sadhu . K. . Russell . P. . Dorée . M. . 1991Natur.351..242S. 4372756 .
• Galaktionov K, Beach D . Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins . Cell . 67 . 6 . 1181–94 . 1992 . 1836978 . 10.1016/0092-8674(91)90294-9 . 9659637 .
• Sadhu K, Reed SI, Richardson H, Russell P . Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 . Proc. Natl. Acad. Sci. U.S.A. . 87 . 13 . 5139–43 . 1990 . 2195549 . 10.1073/pnas.87.13.5139 . 54277 . 1990PNAS...87.5139S . free .
• Re F, Braaten D, Franke EK, Luban J . Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B . J. Virol. . 69 . 11 . 6859–64 . 1995 . 7474100 . 10.1128/JVI.69.11.6859-6864.1995. 189600 .
• Zwicker J . Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1 . Nucleic Acids Res. . 23 . 19 . 3822–30 . 1995 . 7479023 . 10.1093/nar/23.19.3822 . 307297 . Gross C . Lucibello FC . 3 . Truss . Mathias . Ehiert . Frauke . Engeland . Kurt . Müller . Rolf .
• Di Marzio P . Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr . J. Virol. . 69 . 12 . 7909–16 . 1996 . 7494303 . 10.1128/JVI.69.12.7909-7916.1995. 189735 . Choe S . Ebright M . 3 . Knoblauch . R . Landau . NR .
• Strausfeld U . Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis . J. Biol. Chem. . 269 . 8 . 5989–6000 . 1994 . 8119945 . Fernandez A . Capony JP . 3 . Girard . F . Lautredou . N . Derancourt . J . Labbe . JC . Lamb . NJ . 10.1016/S0021-9258(17)37560-9 . free .
• Zheng XF, Ruderman JV . Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25 . Cell . 75 . 1 . 155–64 . 1993 . 8402895 . 10.1016/S0092-8674(05)80092-3 . 45351149 .
• Taviaux SA, Demaille JG . Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization . Genomics . 15 . 1 . 194–6 . 1993 . 8432534 . 10.1006/geno.1993.1032 .
• Honda R . Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase . FEBS Lett. . 318 . 3 . 331–4 . 1993 . 8440392 . 10.1016/0014-5793(93)80540-B . Ohba Y . Nagata A . 3 . Okayama . H . Yasuda . H . 30754963 . free.
• Booher RN, Holman PS, Fattaey A . Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity . J. Biol. Chem. . 272 . 35 . 22300–6 . 1997 . 9268380 . 10.1074/jbc.272.35.22300 . free .
• Sanchez Y . Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 . Science . 277 . 5331 . 1497–501 . 1997 . 9278511 . 10.1126/science.277.5331.1497 . Wong C . Thoma RS . 3 . Richman . R . Wu . Z . Piwnica-Worms . H . Elledge . SJ .

Notes and References

1. Gould KL, Moreno S, Tonks NK, Nurse P . Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase . Science . 250 . 4987 . 1573–6 . Feb 1991 . 1703321 . 10.1126/science.1703321 . 1990Sci...250.1573G . 25037148 .
2. Web site: Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe).
3. Bulavin . D V . Higashimoto Y. Popoff I J. Gaarde W A. Basrur V. Potapova O. Appella E. Fornace A J . May 2001 . Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase . . 411 . 6833 . 102–7 . England. 0028-0836. 11333986 . 10.1038/35075107 . 4410763 .
4. Sanchez . Y . Wong C. Thoma R S. Richman R. Wu Z. Piwnica-Worms H. Elledge S J . Sep 1997 . Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 . . 277 . 5331 . 1497–501 . UNITED STATES. 0036-8075. 9278511 . 10.1126/science.277.5331.1497 .
5. Kawabe . Takumi . Suganuma Masashi . Ando Tomoaki . Kimura Mayumi . Hori Haruna . Okamoto Takashi . Mar 2002 . Cdc25C interacts with PCNA at G2/M transition . Oncogene . 21 . 11 . 1717–26 . England. 0950-9232. 11896603 . 10.1038/sj.onc.1205229 . free .
6. Shen . M . Stukenberg P T. Kirschner M W. Lu K P . Mar 1998 . The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins . Genes Dev. . 12 . 5 . 706–20 . UNITED STATES. 0890-9369. 9499405 . 10.1101/gad.12.5.706 . 316589 .
7. Goldstrohm . A C . Albrecht T R. Suñé C. Bedford M T. Garcia-Blanco M A . Nov 2001 . The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 . Mol. Cell. Biol. . 21 . 22 . 7617–28 . United States. 0270-7306. 11604498 . 10.1128/MCB.21.22.7617-7628.2001 . 99933 .
8. Lu . P J . Zhou X Z. Shen M. Lu K P . Feb 1999 . Function of WW domains as phosphoserine- or phosphothreonine-binding modules . . 283 . 5406 . 1325–8 . UNITED STATES. 0036-8075. 10037602 . 1999Sci...283.1325L . 10.1126/science.283.5406.1325 .
9. Ouyang . B . Li W. Pan H. Meadows J. Hoffmann I. Dai W . Oct 1999 . The physical association and phosphorylation of Cdc25C protein phosphatase by Prk . Oncogene . 18 . 44 . 6029–36 . ENGLAND. 0950-9232. 10557092 . 10.1038/sj.onc.1202983 . free .