CD98 explained
| solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport) |
| Hgncid: | 11026 |
| Symbol: | SLC3A2 |
| Altsymbols: | MDU1, 4T2HC, 4F2, NACAE, CD98 |
| Entrezgene: | 6520 |
| Omim: | 158070 |
| Refseq: | NM_001013251 |
| Uniprot: | P08195 |
| Chromosome: | 11 |
| Arm: | q |
| Band: | 12 |
| Locussupplementarydata: | -q22 |
| solute carrier family 7 member 5 (cationic amino acid transporter, y+ system) |
| Hgncid: | 11063 |
| Symbol: | SLC7A5 |
| Altsymbols: | LAT1, E16, D16S469E, MPE16, CD98 |
| Entrezgene: | 8140 |
| Omim: | 600182 |
| Refseq: | NM_003486 |
| Uniprot: | Q01650 |
| Chromosome: | 16 |
| Arm: | q |
| Band: | 24.3 |
CD98 is a glycoprotein[1] [2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
- 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene [4]
- CD98 light subunit protein encoded by the SLC7A5 gene[5]
See also
Notes and References
- Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D . Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation . Lab. Invest. . 85 . 7 . 932–41 . 2005 . 15880135 . 10.1038/labinvest.3700289 . 19733993 .
- Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G . CD98, a novel marker of transient amplifying human keratinocytes . Proteomics . 5 . 14 . 3637–45 . 2005 . 16097038 . 10.1002/pmic.200401224 . 31954787 .
- Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM . Selective expression of the large neutral amino acid transporter at the blood–brain barrier . Proc. Natl. Acad. Sci. U.S.A. . 96 . 21 . 12079–84 . 1999 . 10518579 . 10.1073/pnas.96.21.12079 . 18415 . 1999PNAS...9612079B . free .
- Palacin M, Kanai Y. The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pflügers Arch . 447 . 5 . 490–494 . 2004. 10.1007/s00424-003-1062-7 . 14770309. 25808108.
- Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y . CATs and HATs: the SLC7 family of amino acid transporters . Pflügers Arch . 447 . 5 . 532–542 . 2004 . 10.1007/s00424-003-1086-z . 14770310. 11670040 .
