LILRA2 explained
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.[1] [2] [3]
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][4]
Function
LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.[5]
See also
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Rojo S, Burshtyn DN, Long EO, Wagtmann N . Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. . J. Immunol. . 158 . 1 . 9–12 . 1997 . 10.4049/jimmunol.158.1.9 . 8977169 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Tedla N, Bandeira-Melo C, Tassinari P, etal . Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 3 . 1174–9 . 2003 . 12529506 . 10.1073/pnas.0337567100 . 298746 . 2003PNAS..100.1174T . free .
- Nakajima H, Asai A, Okada A, etal . Transcriptional regulation of ILT family receptors. . J. Immunol. . 171 . 12 . 6611–20 . 2004 . 14662864 . 10.4049/jimmunol.171.12.6611. free .
- Sloane DE, Tedla N, Awoniyi M, etal . Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. . Blood . 104 . 9 . 2832–9 . 2004 . 15242876 . 10.1182/blood-2004-01-0268 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2)
Notes and References
- Samaridis J, Colonna M . Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways . Eur J Immunol . 27 . 3 . 660–5 . Apr 1997 . 9079806 . 10.1002/eji.1830270313 . 2212182 . free .
- Borges L, Hsu ML, Fanger N, Kubin M, Cosman D . A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules . J Immunol . 159 . 11 . 5192–6 . Apr 1998 . 10.4049/jimmunol.159.11.5192 . 9548455 . 36907307 . free .
- Web site: Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2.
- Web site: Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2.
- Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H . LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins . Nature Microbiology . 1 . 6 . 16054 . Apr 2016 . 10.1038/NMICROBIOL.2016.54. 27572839 . 25500253 .
