CEACAM5 explained

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.^[1]

Functions

In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.^{[2] [3]} Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.^[4] Also, it plays a significant role in the inhibition of differentiation ^[5] and apoptosis ^[6] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.^[7] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).^{[8] [9]}

See also

• Cluster of differentiation

Further reading

• Willcocks TC, Craig IW . Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region . Genomics . 8 . 3 . 492–500 . November 1990 . 2286372 . 10.1016/0888-7543(90)90036-T .
• Barnett T, Zimmermann W . Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family . Tumour Biology . 11 . 1–2 . 59–63 . 1990 . 2309067 . 10.1159/000217643 .
• Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, Shively JE, von Kleist S, Zimmermann W . 6 . Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression . Molecular and Cellular Biology . 10 . 6 . 2738–2748 . June 1990 . 2342461 . 360634 . 10.1128/MCB.10.6.2738 .
• Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, Nedwin JJ, Barnett TR . 6 . Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11 . Proceedings of the National Academy of Sciences of the United States of America . 84 . 15 . 5350–5354 . August 1987 . 2955415 . 298853 . 10.1073/pnas.84.15.5350 . free . 1987PNAS...84.5350K .
• Zimmermann W, Ortlieb B, Friedrich R, von Kleist S . Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure . Proceedings of the National Academy of Sciences of the United States of America . 84 . 9 . 2960–2964 . May 1987 . 3033671 . 304780 . 10.1073/pnas.84.9.2960 . free . 1987PNAS...84.2960Z .
• Barnett T, Goebel SJ, Nothdurft MA, Elting JJ . Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains . Genomics . 3 . 1 . 59–66 . July 1988 . 3220478 . 10.1016/0888-7543(88)90160-7 .
• Zimmermann W, Weber B, Ortlieb B, Rudert F, Schempp W, Fiebig HH, Shively JE, von Kleist S, Thompson JA . 6 . Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors . Cancer Research . 48 . 9 . 2550–2554 . May 1988 . 3356015 .
• Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP . Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen . Molecular and Cellular Biology . 7 . 9 . 3221–3230 . September 1987 . 3670312 . 367958 . 10.1128/MCB.7.9.3221 .
• Oikawa S, Nakazato H, Kosaki G . Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence . Biochemical and Biophysical Research Communications . 142 . 2 . 511–518 . January 1987 . 3814146 . 10.1016/0006-291X(87)90304-4 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hart SP, Ross JA, Ross K, Haslett C, Dransfield I . Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes . Cell Death and Differentiation . 7 . 5 . 493–503 . May 2000 . 10800083 . 10.1038/sj.cdd.4400680 . free .
• Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL . Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells . Infection and Immunity . 68 . 6 . 3554–3563 . June 2000 . 10816511 . 97642 . 10.1128/IAI.68.6.3554-3563.2000 .
• Boehm MK, Perkins SJ . Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23 . FEBS Letters . 475 . 1 . 11–16 . June 2000 . 10854848 . 10.1016/S0014-5793(00)01612-4 . 5765612 . free .
• Screaton RA, DeMarte L, Dráber P, Stanners CP . The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor . The Journal of Cell Biology . 150 . 3 . 613–626 . August 2000 . 10931872 . 2175204 . 10.1083/jcb.150.3.613 .
• Bajenova OV, Zimmer R, Stolper E, Salisbury-Rowswell J, Nanji A, Thomas P . Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells . The Journal of Biological Chemistry . 276 . 33 . 31067–31073 . August 2001 . 11406629 . 10.1074/jbc.M104093200 . free .
• Wirth T, Soeth E, Czubayko F, Juhl H . Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth . Clinical & Experimental Metastasis . 19 . 2 . 155–160 . 2002 . 11964079 . 10.1023/A:1014566127493 . 3138022 .
• Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C . Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer . International Journal of Cancer . 101 . 6 . 545–548 . October 2002 . 12237895 . 10.1002/ijc.90009 . 7030523 . free .
• Hampton R, Walker M, Marshall J, Juhl H . Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells . Oncogene . 21 . 51 . 7817–7823 . November 2002 . 12420218 . 10.1038/sj.onc.1205906 . free .

External links

• • • PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)

Notes and References

1. Web site: Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5.
2. Beauchemin N, Arabzadeh A . Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis . Cancer and Metastasis Reviews . 32 . 3–4 . 643–671 . December 2013 . 23903773 . 10.1007/s10555-013-9444-6 . 10344352 .
3. Zhang X, Han X, Zuo P, Zhang X, Xu H . CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration . The Journal of International Medical Research . 48 . 9 . 300060520959478 . September 2020 . 32993395 . 7536504 . 10.1177/0300060520959478 .
4. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP . Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule . Cell . 57 . 2 . 327–334 . April 1989 . 2702691 . 10.1016/0092-8674(89)90970-7 . 30740594 .
5. Ilantzis C, DeMarte L, Screaton RA, Stanners CP . Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation . Neoplasia . 4 . 2 . 151–163 . 2002 . 11896570 . 1550325 . 10.1038/sj.neo.7900201 .
6. Ordoñez C, Screaton RA, Ilantzis C, Stanners CP . Human carcinoembryonic antigen functions as a general inhibitor of anoikis . Cancer Research . 60 . 13 . 3419–3424 . July 2000 . 10910050 .
7. Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, Kaprin A, Zgoda V, Yarygin K, Lupatov A . 6 . CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells . Cancer Biomarkers . 32 . 1 . 85–98 . 2021-01-01 . 34092615 . 10.3233/CBM-203187 . 235359543 .
8. LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, Nguyen Q, Ren J, Srdanov MR, Tanna V, Thakrar S . 6 . 2021-05-20 . Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701). . Journal of Clinical Oncology . en . 39 . 15_suppl . e21030 . 10.1200/JCO.2021.39.15_suppl.e21030 . 236398737 . 0732-183X.
9. Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS . Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates . Frontiers in Oncology . 13 . 1124039 . 2023-02-27 . 36923424 . 10010383 . 10.3389/fonc.2023.1124039 . free .