CD53 explained

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.^{[1] [2]}

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.

See also

• Cluster of differentiation
• Tetraspanin

Further reading

• Horejsí V, Vlcek C . Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63 . FEBS Lett. . 288 . 1–2 . 1–4 . 1991 . 1879540 . 10.1016/0014-5793(91)80988-F . 26316623 . free .
• Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye . J. Cell Sci. . 114 . Pt 23 . 4143–51 . 2002 . 10.1242/jcs.114.23.4143 . 11739647 .
• Bell GM, Seaman WE, Niemi EC, Imboden JB . The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line . J. Exp. Med. . 175 . 2 . 527–536 . 1992 . 1346273 . 10.1084/jem.175.2.527 . 2119111 .
• Angelisová P . The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens . Immunogenetics . 32 . 4 . 281–285 . 1990 . 1700763 . 10.1007/BF00187099 . Vlcek C . Stefanová I . 3 . Lipoldová . Marie . Hořejší . Václav . 42139537 .
• Amiot M . Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins . J. Immunol. . 145 . 12 . 4322–5 . 1991 . 10.4049/jimmunol.145.12.4322 . 2258620 . free .
• Dianzani U . Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120 . Eur. J. Immunol. . 25 . 5 . 1306–1311 . 1995 . 7539755 . 10.1002/eji.1830250526 . Bragardo M . Buonfiglio D . 3 . Redoglia . Valter . Funaro . Ada . Portoles . Pilar . Rojo . José . Malavasi . Fabio . Pileri . Alessandro . 37717142 .
• Carmo AM, Wright MD . Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity . Eur. J. Immunol. . 25 . 7 . 2090–2095 . 1995 . 7621882 . 10.1002/eji.1830250743 . 44551148 .
• Rasmussen AM . Cross-linking of CD53 promotes activation of resting human B lymphocytes . J. Immunol. . 153 . 11 . 4997–5007 . 1994 . 7963560 . Blomhoff HK . Stokke T . 3 . Horejsi . V . Smeland . EB . 10.4049/jimmunol.153.11.4997 . free .
• Gonzalez ME . The human CD53 gene, coding for a four transmembrane domain protein, maps to chromosomal region 1p13 . Genomics . 18 . 3 . 725–728 . 1994 . 8307585 . 10.1016/S0888-7543(05)80385-4 . Pardo-Manuel de Villena F . Fernandez-Ruiz E . 3 . Rodriguezdecordoba . S . Lazo . P . 10261/72861 . free.
• Olweus J, Lund-Johansen F, Horejsi V . CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells . J. Immunol. . 151 . 2 . 707–16 . 1993 . 10.4049/jimmunol.151.2.707 . 8335905 . free .
• Taguchi T . Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents . Cytogenet. Cell Genet. . 64 . 3–4 . 217–221 . 1993 . 8404042 . 10.1159/000133580 . Bellacosa A . Zhou JY . 3 . Gilbert . D.J. . Lazo . P.A. . Copeland . N.G. . Jenkins . N.A. . Tsichlis . P.N. . Testa . J.R. .
• Virtaneva KI . The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes . Immunogenetics . 37 . 6 . 461–465 . 1993 . 8436422 . 10.1007/BF00222471 . Angelisová P . Baumruker T . 3 . Hořejší . Václav . Nevanlinna . Heli . Schröder . Jim . 10138/157839 . 8899453 . free.
• Wright MD . Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication . Int. Immunol. . 5 . 2 . 209–216 . 1993 . 8452817 . 10.1093/intimm/5.2.209 . Rochelle JM . Tomlinson MG . 3 . Seldin . Michael F. . Williams . Alan F. .
• Mannion BA . Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29) . J. Immunol. . 157 . 5 . 2039–47 . 1996 . 8757325 . Berditchevski F . Kraeft SK . 3 . Chen . LB . Hemler . ME . 10.4049/jimmunol.157.5.2039 . free .
• Szöllósi J . Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY . J. Immunol. . 157 . 7 . 2939–46 . 1996 . 8816400 . Horejsí V . Bene L . 3 . Angelisová . P . Damjanovich . S . 10.4049/jimmunol.157.7.2939 . free .
• Okochi H . Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human keratinocytes: an association of CD9 with alpha 3 beta 1 integrin . Br. J. Dermatol. . 137 . 6 . 856–863 . 1998 . 9470900 . 10.1111/j.1365-2133.1997.tb01544.x . Kato M . Nashiro K . 3 . Yoshie . O. . Miyazono . K. . Furue . M. .
• Nichols TC . Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes . Eur. J. Immunol. . 28 . 12 . 4123–4129 . 1999 . 9862348 . 10.1002/(SICI)1521-4141(199812)28:12<4123::AID-IMMU4123>3.0.CO;2-G . Guthridge JM . Karp DR . 3 . Molina . Hector . Fletcher . Dana R. . Holers . V. Michael . 1333672 . free.
• Serru V . Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions . Biochem. J. . 340 . 1 . 103–11 . 1999 . 10229664 . 10.1042/0264-6021:3400103 . 1220227 . Le Naour F . Billard M . 3 . Azorsa . David O. . Lanza . François . Boucheix . Claude . Rubinstein . Eric .

Notes and References

1. Korinek V, Horejsi V . Genomic structure of the human CD53 gene . Immunogenetics . 38 . 4 . 272–279 . Jul 1993 . 8319976 . 10.1007/BF00188803 . 6683727 .
2. Web site: Entrez Gene: CD53 CD53 molecule.