GP5 (gene) explained

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.^[1]

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 193400) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.[supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE . Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. . J. Biol. Chem. . 267 . 1 . 364–9 . 1992 . 10.1016/S0021-9258(18)48503-1 . 1730602 . free .
• Shimomura T, Fujimura K, Maehama S . Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib. . Blood . 75 . 12 . 2349–56 . 1990 . 2350580 . 10.1182/blood.V75.12.2349.2349. etal. free .
• Roth GJ, Church TA, McMullen BA, Williams SA . Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion. . Biochem. Biophys. Res. Commun. . 170 . 1 . 153–61 . 1990 . 2372284 . 10.1016/0006-291X(90)91253-O .
• Hickey MJ, Hagen FS, Yagi M, Roth GJ . Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 90 . 18 . 8327–31 . 1993 . 7690959 . 10.1073/pnas.90.18.8327 . 47349 . 1993PNAS...90.8327H . free .
• Meyer SC, Fox JE . Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. . J. Biol. Chem. . 270 . 24 . 14693–9 . 1995 . 7782333 . 10.1074/jbc.270.24.14693 . free .
• Takafuta T, Fujimura K, Kawano H . Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a novel monoclonal antibody against GPV. . Thromb. Haemost. . 72 . 5 . 762–9 . 1995 . 7900083 . etal.
• Lanza F, Morales M, de La Salle C . Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. . J. Biol. Chem. . 268 . 28 . 20801–7 . 1993 . 10.1016/S0021-9258(19)36855-3 . 8407908 . etal. free .
• Yagi M, Edelhoff S, Disteche CM, Roth GJ . Human platelet glycoproteins V and IX: mapping of two leucine-rich glycoprotein genes to chromosome 3 and analysis of structures. . Biochemistry . 34 . 49 . 16132–7 . 1996 . 8519770 . 10.1021/bi00049a028 .
• Berger G, Massé JM, Cramer EM . Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V. . Blood . 87 . 4 . 1385–95 . 1996 . 8608228 . 10.1182/blood.V87.4.1385.bloodjournal8741385. free .
• Ravanat C, Morales M, Azorsa DO . Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. . Blood . 89 . 9 . 3253–62 . 1997 . 9129030 . 10.1182/blood.V89.9.3253. etal. free .
• Bradford HN, Dela Cadena RA, Kunapuli SP . Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. . Blood . 90 . 4 . 1508–15 . 1997 . 9269768 . 10.1182/blood.V90.4.1508. etal. free .
• Wu G, Essex DW, Meloni FJ . Human endothelial cells in culture and in vivo express on their surface all four components of the glycoprotein Ib/IX/V complex. . Blood . 90 . 7 . 2660–9 . 1997 . 9326233 . 10.1182/blood.V90.7.2660. etal. free .
• Andrews RK, Harris SJ, McNally T, Berndt MC . Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. . Biochemistry . 37 . 2 . 638–47 . 1998 . 9425086 . 10.1021/bi970893g .
• Longhurst CM, White MM, Wilkinson DA, Jennings LK . A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. . Eur. J. Biochem. . 263 . 1 . 104–11 . 1999 . 10429193 . 10.1046/j.1432-1327.1999.00467.x .
• Dicker IB, Pedicord DL, Seiffert DA . Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. . Thromb. Haemost. . 86 . 4 . 1065–9 . 2002 . 11686325 . etal.
• Rabie T, Strehl A, Ludwig A, Nieswandt B . Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. . J. Biol. Chem. . 280 . 15 . 14462–8 . 2005 . 15691827 . 10.1074/jbc.M500041200 . free .
• Aktas B, Pozgajova M, Bergmeier W . Aspirin induces platelet receptor shedding via ADAM17 (TACE). . J. Biol. Chem. . 280 . 48 . 39716–22 . 2006 . 16179345 . 10.1074/jbc.M507762200 . etal. free .
• Lewandrowski U, Moebius J, Walter U, Sickmann A . Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. . Mol. Cell. Proteomics . 5 . 2 . 226–33 . 2006 . 16263699 . 10.1074/mcp.M500324-MCP200 . 7856143 . free .

Notes and References

1. Web site: Entrez Gene: GP5 glycoprotein V (platelet).