Glycoprotein IX explained

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.^[1]

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• Kunishima S, Kamiya T, Saito H . Genetic abnormalities of Bernard-Soulier syndrome . Int. J. Hematol. . 76 . 4 . 319–27 . 2003 . 12463594 . 10.1007/BF02982690 . 23635810 .
• Hickey MJ, Deaven LL, Roth GJ . Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3 . FEBS Lett. . 274 . 1–2 . 189–92 . 1991 . 2253772 . 10.1016/0014-5793(90)81361-Q . 12468752 . free .
• Du X, Beutler L, Ruan C, etal . Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane . Blood . 69 . 5 . 1524–7 . 1987 . 2436691 . 10.1182/blood.V69.5.1524.1524. free .
• Andrews RK, Booth WJ, Gorman JJ, etal . Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex . Biochemistry . 28 . 21 . 8317–26 . 1990 . 2557900 . 10.1021/bi00447a009 .
• Hickey MJ, Williams SA, Roth GJ . Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures . Proc. Natl. Acad. Sci. U.S.A. . 86 . 17 . 6773–7 . 1989 . 2771955 . 10.1073/pnas.86.17.6773 . 297928 . 1989PNAS...86.6773H . free .
• Roth GJ, Ozols J, Nugent DJ, Williams SA . Isolation and characterization of human platelet glycoprotein IX . Biochem. Biophys. Res. Commun. . 156 . 2 . 931–9 . 1988 . 3056407 . 10.1016/S0006-291X(88)80933-1 .
• Meyer SC, Fox JE . Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells . J. Biol. Chem. . 270 . 24 . 14693–9 . 1995 . 7782333 . 10.1074/jbc.270.24.14693 . free .
• Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ . Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX . Blood . 84 . 4 . 1124–31 . 1994 . 8049428 . 10.1182/blood.V84.4.1124.1124. free .
• Hickey MJ, Roth GJ . Characterization of the gene encoding human platelet glycoprotein IX . J. Biol. Chem. . 268 . 5 . 3438–43 . 1993 . 10.1016/S0021-9258(18)53713-3 . 8429020 . free .
• Wright SD, Michaelides K, Johnson DJ, etal . Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome . Blood . 81 . 9 . 2339–47 . 1993 . 8481514 . 10.1182/blood.V81.9.2339.2339. free .
• Berger G, Massé JM, Cramer EM . Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V . Blood . 87 . 4 . 1385–95 . 1996 . 8608228 . 10.1182/blood.V87.4.1385.bloodjournal8741385. free .
• Hollmann C, Haag F, Schlott M, etal . Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products . Mol. Immunol. . 33 . 9 . 807–17 . 1996 . 8811076 . 10.1016/0161-5890(96)00008-9 .
• Noris P, Simsek S, Stibbe J, von dem Borne AE . A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome . Br. J. Haematol. . 97 . 2 . 312–20 . 1997 . 9163595 . 10.1046/j.1365-2141.1997.582706.x . 19759549 . free .
• Hayashi T, Suzuki K, Yahagi A, etal . Corrected DNA sequence of the platelet glycoprotein IX gene . Thromb. Haemost. . 77 . 5 . 1034–5 . 1997 . 9184424 . 10.1055/s-0038-1656099. 6328233 .
• Bradford HN, Dela Cadena RA, Kunapuli SP, etal . Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex . Blood . 90 . 4 . 1508–15 . 1997 . 9269768 . 10.1182/blood.V90.4.1508. free .
• Suzuki K, Hayashi T, Yahagi A, etal . Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome . Br. J. Haematol. . 99 . 4 . 794–800 . 1998 . 9432024 . 10.1046/j.1365-2141.1997.4753275.x . 20513918 . free .
• Noris P, Arbustini E, Spedini P, etal . A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV . Br. J. Haematol. . 103 . 4 . 1004–13 . 1999 . 9886312 . 10.1046/j.1365-2141.1998.01100.x . 7435503 . free .
• Longhurst CM, White MM, Wilkinson DA, Jennings LK . A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states . Eur. J. Biochem. . 263 . 1 . 104–11 . 1999 . 10429193 . 10.1046/j.1432-1327.1999.00467.x .
• Kunishima S, Tomiyama Y, Honda S, etal . Cys97→Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome . Br. J. Haematol. . 107 . 3 . 539–45 . 2000 . 10583255 . 10.1046/j.1365-2141.1999.01733.x . 28086704 .
• Rivera CE, Villagra J, Riordan M, etal . Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome . Br. J. Haematol. . 112 . 1 . 105–8 . 2001 . 11167791 . 10.1046/j.1365-2141.2001.02529.x . 887208 . free .

Notes and References

1. Web site: Entrez Gene: GP9 glycoprotein IX (platelet).