CD3G explained

T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene.

T cell antigen receptor (TCR) is associated on the T cell surface with a complex of protein called CD3. CD3G (gamma chain) is one of the four peptides (gamma, delta, epsilon and zeta) that form CD3. Defects in CD3G are associated with T cell immunodeficiency.^[1]

See also

• CD3 (immunology)
• Cluster of differentiation

Further reading

• Joseph AM, Kumar M, Mitra D . Nef: "necessary and enforcing factor" in HIV infection. . Curr. HIV Res. . 3 . 1 . 87–94 . 2005 . 15638726 . 10.2174/1570162052773013 .
• Li CJ . Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference. . J. Cell. Physiol. . 209 . 3 . 695–700 . 2007 . 17001685 . 10.1002/jcp.20817 . 37846031 .
• Luzzati AL, Giacomini E, Giordani L . The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. . Immunol. Lett. . 33 . 3 . 307–14 . 1992 . 1385321 . 10.1016/0165-2478(92)90078-3 . etal.
• Lanier LL, Chang C, Spits H, Phillips JH . Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes. . J. Immunol. . 149 . 6 . 1876–80 . 1992 . 10.4049/jimmunol.149.6.1876 . 1387664 . free .
• Letourneur F, Klausner RD . A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. . Cell . 69 . 7 . 1143–57 . 1992 . 1535555 . 10.1016/0092-8674(92)90636-Q . 32641759 .
• Arnaiz-Villena A, Timon M, Corell A . Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor. . N. Engl. J. Med. . 327 . 8 . 529–33 . 1992 . 1635567 . 10.1056/NEJM199208203270805 . etal. free .
• Arnaiz-Villena A, Perez-Aciego P, Ballestin C . Biochemical basis of a novel T lymphocyte receptor immunodeficiency by immunohistochemistry. A possible CD3 gamma abnormality. . Lab. Invest. . 64 . 5 . 675–81 . 1991 . 1709425 . etal.
• Alarcón B, Ley SC, Sánchez-Madrid F . The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes . EMBO J. . 10 . 4 . 903–12 . 1991 . 1826255 . 10.1002/j.1460-2075.1991.tb08023.x. 452733 . etal.
• Ruegg CL, Strand M . A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx . Cell. Immunol. . 137 . 1 . 1–13 . 1991 . 1832084 . 10.1016/0008-8749(91)90051-C . free .
• Cefai D, Debre P, Kaczorek M . Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway . J. Clin. Invest. . 86 . 6 . 2117–24 . 1991 . 1979339 . 10.1172/JCI114950 . 329852 . etal.
• Luzzati AL, Pugliese O, Giacomini E . Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV . Folia Biol. (Praha) . 36 . 1 . 71–7 . 1990 . 2111780 . etal.
• Koning F, Maloy WL, Coligan JE . The implications of subunit interactions for the structure of the T cell receptor-CD3 complex . Eur. J. Immunol. . 20 . 2 . 299–305 . 1990 . 2138083 . 10.1002/eji.1830200211 . 2180901 .
• Ruegg CL, Strand M . Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41 . J. Immunol. . 144 . 10 . 3928–35 . 1990 . 10.4049/jimmunol.144.10.3928 . 2139676 . free .
• Alexander D, Goris J, Marais R . Dephosphorylation of the human T lymphocyte CD3 antigen . Eur. J. Biochem. . 181 . 1 . 55–65 . 1989 . 2540970 . 10.1111/j.1432-1033.1989.tb14693.x . etal.
• Griesinger F, Greenberg JM, Kersey JH . T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation . J. Clin. Invest. . 84 . 2 . 506–16 . 1989 . 2547833 . 10.1172/JCI114193 . 548910 .
• Tunnacliffe A, Buluwela L, Rabbitts TH . Physical linkage of three CD3 genes on human chromosome 11 . EMBO J. . 6 . 10 . 2953–7 . 1988 . 2826124 . 10.1002/j.1460-2075.1987.tb02600.x. 553731 .
• Krissansen GW, Owen MJ, Verbi W, Crumpton MJ . Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits . EMBO J. . 5 . 8 . 1799–808 . 1986 . 2944745 . 10.1002/j.1460-2075.1986.tb04429.x. 1167043 .
• Davies AA, Cantrell DA, Hexham JM . The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation . J. Biol. Chem. . 262 . 23 . 10918–21 . 1987 . 10.1016/S0021-9258(18)60903-2 . 3112151 . etal. free .
• Gold DP, Clevers H, Alarcon B . Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family . Proc. Natl. Acad. Sci. U.S.A. . 84 . 21 . 7649–53 . 1987 . 3478717 . 10.1073/pnas.84.21.7649 . 299357 . 1987PNAS...84.7649G . etal. free .
• Oravecz T, Norcross MA . Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120 . AIDS Res. Hum. Retroviruses . 9 . 10 . 945–55 . 1994 . 7506554 . 10.1089/aid.1993.9.945 .

Notes and References

1. Web site: Entrez Gene: CD3G CD3g molecule, gamma (CD3-TCR complex).