CD3EAP explained

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene.^{[1] [2] [3] [4]}

Interactions

CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain, POLR1E and POLR1C.^[3]

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Bouwmeester T, Bauch A, Ruffner H . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ma J, Dempsey AA, Stamatiou D . Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. . Atherosclerosis . 191 . 1 . 63–72 . 2007 . 16806233 . 10.1016/j.atherosclerosis.2006.05.032 . etal.
• Panov KI, Panova TB, Gadal O . RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. . Mol. Cell. Biol. . 26 . 14 . 5436–48 . 2006 . 16809778 . 10.1128/MCB.00230-06 . 1592716 . etal.
• Skjelbred CF, Saebø M, Nexø BA . Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. . BMC Cancer . 6. 175 . 2006 . 16817948 . 10.1186/1471-2407-6-175 . 1533843 . etal . free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.

Notes and References

1. Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T . CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells . J Biol Chem . 274 . 26 . 18173–80 . Jul 1999 . 10373416 . 10.1074/jbc.274.26.18173 . free .
2. Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB . ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes . Chromosoma . 106 . 8 . 493–502 . Mar 1998 . 9426281 . 10.1007/s004120050271 . 10684078 .
3. Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M . Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription . Mol Cell Biol . 24 . 14 . 6338–49 . Jun 2004 . 15226435 . 434256 . 10.1128/MCB.24.14.6338-6349.2004 .
4. Web site: Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein.