CD3D explained

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.^[1]

Interactions

CD3D has been shown to interact with CD8A.^[2]

See also

• CD3 (immunology)
• Cluster of differentiation

Further reading

• Balk SP, Polischuk JE, Probert C . Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. . Int. Immunol. . 7 . 8 . 1237–41 . 1996 . 7495730 . 10.1093/intimm/7.8.1237 . etal.
• Li CJ . Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference. . J. Cell. Physiol. . 209 . 3 . 695–700 . 2007 . 17001685 . 10.1002/jcp.20817 . 37846031 .
• Phillips JH, Hori T, Nagler A . Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins. . J. Exp. Med. . 175 . 4 . 1055–66 . 1992 . 1372642 . 10.1084/jem.175.4.1055 . 2119193 . etal.
• Luzzati AL, Giacomini E, Giordani L . The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. . Immunol. Lett. . 33 . 3 . 307–14 . 1992 . 1385321 . 10.1016/0165-2478(92)90078-3 . etal.
• Alarcón B, Ley SC, Sánchez-Madrid F . The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. . EMBO J. . 10 . 4 . 903–12 . 1991 . 1826255 . 10.1002/j.1460-2075.1991.tb08023.x. 452733 . etal.
• Hori T, de Waal Malefyt R, Duncan BW . Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3. . Int. Immunol. . 3 . 4 . 353–7 . 1991 . 1831653 . 10.1093/intimm/3.4.353 . etal.
• Ruegg CL, Strand M . A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. . Cell. Immunol. . 137 . 1 . 1–13 . 1991 . 1832084 . 10.1016/0008-8749(91)90051-C . free .
• Cefai D, Debre P, Kaczorek M . Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. . J. Clin. Invest. . 86 . 6 . 2117–24 . 1991 . 1979339 . 10.1172/JCI114950 . 329852 . etal.
• Luzzati AL, Pugliese O, Giacomini E . Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV. . Folia Biol. (Praha) . 36 . 1 . 71–7 . 1990 . 2111780 . etal.
• Koning F, Maloy WL, Coligan JE . The implications of subunit interactions for the structure of the T cell receptor-CD3 complex. . Eur. J. Immunol. . 20 . 2 . 299–305 . 1990 . 2138083 . 10.1002/eji.1830200211 . 2180901 .
• Alexander D, Goris J, Marais R . Dephosphorylation of the human T lymphocyte CD3 antigen. . Eur. J. Biochem. . 181 . 1 . 55–65 . 1989 . 2540970 . 10.1111/j.1432-1033.1989.tb14693.x . etal.
• Tunnacliffe A, Buluwela L, Rabbitts TH . Physical linkage of three CD3 genes on human chromosome 11. . EMBO J. . 6 . 10 . 2953–7 . 1988 . 2826124 . 10.1002/j.1460-2075.1987.tb02600.x. 553731 .
• van den Elsen P, Shepley BA, Cho M, Terhorst C . Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. . Nature . 314 . 6011 . 542–4 . 1985 . 2859526 . 10.1038/314542a0 . 1985Natur.314..542V . 4321989 .
• van den Elsen P, Georgopoulos K, Shepley BA . Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. . Proc. Natl. Acad. Sci. U.S.A. . 83 . 9 . 2944–8 . 1986 . 2939461 . 10.1073/pnas.83.9.2944 . 323423 . 1986PNAS...83.2944V . etal. free .
• Gold DP, Clevers H, Alarcon B . Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. . Proc. Natl. Acad. Sci. U.S.A. . 84 . 21 . 7649–53 . 1987 . 3478717 . 10.1073/pnas.84.21.7649 . 299357 . etal. 1987PNAS...84.7649G. free .
• Tunnacliffe A, Sims JE, Rabbitts TH . T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells. . EMBO J. . 5 . 6 . 1245–52 . 1986 . 3488209 . 10.1002/j.1460-2075.1986.tb04353.x. 1166934 .
• van den Elsen P, Shepley BA, Borst J . Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. . Nature . 312 . 5993 . 413–8 . 1985 . 6095101 . 10.1038/312413a0 . etal. 1984Natur.312..413V . 4347265 .
• Oravecz T, Norcross MA . Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120. . AIDS Res. Hum. Retroviruses . 9 . 10 . 945–55 . 1994 . 7506554 . 10.1089/aid.1993.9.945 .
• Luzzati AL, Giacomini E, Giordani L . An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex. . Cell. Immunol. . 156 . 2 . 286–95 . 1994 . 7517794 . 10.1006/cimm.1994.1175 . etal.

External links

• • • PDBe-KB provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)

Notes and References

1. Web site: Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex).
2. Doucey . Marie-Agnès . Goffin Laurence . Naeher Dieter . Michielin Olivier . Baumgärtner Petra . Guillaume Philippe . Palmer Ed . Luescher Immanuel F . Jan 2003 . CD3 delta establishes a functional link between the T cell receptor and CD8 . J. Biol. Chem. . 278 . 5 . 3257–64 . United States. 0021-9258. 12215456 . 10.1074/jbc.M208119200 . free.